methylation

Methylation, the addition to a base of a group of three hydrogens and a carbon atom, is one way in which genes are regulated.

Researchers looked for - and found - a chemical change called DNA methylation in healthy tissue adjacent to breast tumors.

Scientists have several reasons to suspect that this methylation pattern might contribute to autoimmunity .

Consistent with these important roles, a growing number of human diseases have been found to be associated with aberrant DNA methylation.

In malignant cell the pattern of DNA methylation, as well as the set of DNA methyltransferase activities, differs from that in normal cell.

DNA methylation is one of the most common epigenetic events occurring in human genome and is implicated in cancer.

METHODS Sugar composition analysis, methylation analysis and NMR were used to determine the structural features.

This results in a considerable reduction in the time required for completion of a detailed genomic methylation project.

Methylation is an epigenetic modification to one's DNA that changes a gene's activity, generally reducing that activity within the genome.

It can be thus suggested, that the plant cell contains at least two different, and probably, interdependent systems of DNA methylation.

In the case of stress, previous studies have suggested that methylation of the gene which encodes glucocorticoid receptors is important.

Methylation of cytosine residues is one of the most versatile mechanisms of epigenetic regulation.

Bisulphite genomic sequencing is a widely used technique for detailed analysis of the methylation status of a region of DNA.

The aetiology of RSS is still unclear but it has been correlated with the degrees of gene methylation.

Whether cytosine methylation is the explanation for this difference has yet to be tested, but something is clearly happening.

DNA methylation is a chemical modification made to DNA that plays an important role in dictating how DNA is read and interpreted by a cell.

The work is one of several clues that DNA methylation affects the formation and maintenance of memories.

One of the best known epigenetic factors is DNA methylation, which is a major mechanism for regulation of gene expression.

Therefore, profiling DNA methylation across the genome is vital to understanding the influence of epigenetics.

For how the methylation was involved in muscle development and myogenin gene regulation precisely requires further study to prove.

DNA methylation is an important epigenetic modification which regulates a number of biological processes.

Malignant gliomas often have the MGMT gene inactivated due to aberrant methylation of its promoter region.

Genes suppressed by this methylation include tumor suppressors that would otherwise prevent cancer growth and spread.

Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials.

DNA methylation is one of the most common epigenetic events in eukaryotic cell.

However, then injecting them with a drug to inhibit methylation seemed to erase any memory of the shock.

The inactivation of antioncogene by methylation has become one of important pathogenesis mechanisms of leukemia.

Results indicate that the primary productivity is an important indicator of Hg methylation in reservoirs.

The code written on his tones consists of post-translational modifications, including acetylation and methylation.

What happens to the unbranched glucose residues in amylopectin during the methylation and hydrolysis procedure?

In plants, aberrant RNA signals direct DNA methylation to target sequences, sometimes appropriately and sometimes inappropriately.

Aberrant DNA methylation is one of the major characteristics of tumor cells in addition to genetic and other epigenetic alterations.

Various factors can influence methylation, including environmental conditions.

However, there is such a diversity of DNA methylation profiling techniques that it can be challenging to select one.

This methylation is associated with gene silencing, as it causes the DNA's double helix to fold even tighter upon itself.

Replication of methylation patterns by DNA methyltransferases maintains genome stability through cell division.

The methylation of histone lysine is an important covalent modification at its tails and plays a key role in epigenetic regulation.

DNA methylation, catalyzed by methyltransferases, is a normal epigenetic DNA modification approach in eukaryotic cells.

Here, we review the advances in this field, meanwhile, function of DNA methylation in recombination suppression is being analysed briefly.

This study did not reveal the interaction between polymorphism of GSTM1and CYP1A1 gene and methylation of P16 in lung cancer.

Many studies showed that DNA methylation is specific marker of NSCLC in its diagnosis, staging, treatment and prognosis.

DNA methylation plays an important role in gene expression regulation during biological development and tissue differentiation in plants.

In particular, the discovery of changes of the methylation level during cancer development has increased the interest in this field.

Three candidate methylation differences were validated by targeted pyrosequencing assays.

Methylation protects the kidneys and stimulates production of the fat-transporting molecule l-carnitine.

The analysis of DNA methylation in plasma will have the powerful potentiality that applicate to noninvasive prenatal diagnosis.

Differential histone modification marks of active versus repressed genes accompany these DNA methylation changes.

BACKGROUND: Gene promoter methylation is an epigenetic event leading to gene silencing.

Both DNA methylation and histone modification are involved in establishing patterns of gene repression during development.

Folate metabolism plays a key role in maintaining normal intracellular methylation, DNA synthesis and repair, and genome stability.

DNA methylation is a major epigenetic modification and plays a crucial role in embryonic development and placentas'development.

Thus, the DNA methylation is imposed on the transition between the active versus repressed transcription state for CD133 only in tumors.

This epigenetic information can be introduced by cytosine methylation and by marking nucleosomal histones.

AIM: To explore the relationship of methylation status and expression of spleen tyrosine kinase (Syk) gene in colorectal cancer cell lines.

Pronounced asymmetry of the DNA strand methylation disappears to the end of the cell cycle.

It stores information about the origin of the investigated sample and the experimental procedure, and contains the DNA methylation data.

Arsenic can damage DNA , inhibit restoring of DNA, cause chromosomal mutation, and induce cell apoptosis and methylation.

MTHFR activity can guarantee the normal metabolism of folate, DNA synthesis and methylation of the normal.

We present here a database for DNA methylation data that attempts to unify these results in a common resource.

Reduction, methylation and demethylation were important mechanisms of Hg speciation in both the water column and the benthic sediment.

In plants inhibition of DNA methylation is accompanied by the induction of seed storage and florescence genes.

Nor was the mother's own methylation affected by violence towards her.

A methylation-capillary GC method was established for the determination of trans-fatty acids in lipid emulsion.

In this review, we discuss some general themes in DNA methylation analysis and outline the basic principles of current key techniques.

DNA methylation has an important role in transcriptional regulation, togethering with histone modification and chromatin remodeling.

In particular, the discovery of changes in the methylation level during cancer development has increased the interest in this field.

DNA methylation is one of the most important and distinct forms of epigenetic modification.

In plants, DNA methylation is regulated by a complex interplay between several methylating and demethylating enzymes.

Mercury methylation by microbes plays a key role in mercury biogeochemical cycle, and closely related with public health.

DNA methylation contributes to the control of gene expression and plays an essential role in cellular physiology.

Although researches in this area have been reported, but DNA methylation in the hybrid variations of inter-generational studys are rare.

The advent of microarray technology has provided new opportunities for high-throughput study on DNA methylation.

This review mainly focuses on recent advances in histone methylation effector protein's function mechanism.

In some cases, the substrate of methylation can be inferred from hidden Markov model sequence similarity networks.

But in the daughters of obese fathers, the level of methylation of this gene was around 25% of the level seen in the control daughters.

DNA methylation patterns are set up early in mammalian development and are then copied during the division of somatic cells.

According to many researches, the variation of DNA methylation can be transferred to the offspring by cell division.

Here, we present an in situ method for DNA methylation analysis, which has high sensitivity and good reproducibility.

Objective To investigate the relationship between promoter methylation of RASSF1A gene and laryngeal squamous cell carcinoma.

New techniques are making it easier to map DNA methylation patterns on a large scale and the results have already provided surprises.

The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine.

Histone lysine methylation plays a key role in the organization of chromatin structure and the regulation of gene expression.

Its DNA is reprogrammed, the theory goes, by a process called cytosine methylation.

DNA methylation is the unique natural covalent modification of vertebrate animals.

DNA methylation is a prominent epigenetic mark and extensively found within plant genomes.

Methylation of SFRP genes may serve as potential independent biomarkers for early detection of hematologic malignancies.

Decitabine is the most common medicament used to reduce the level of methylation.

Global methylation dynamics in seeds of cereal crops that provide the bulk of human nutrition remain unknown.

In the histone code the methylation target is known as H3K9, where K stands for lysine.

Recent evidence indicates that DNA methylation is a promising biomarker for cancer.

In this review, we summarized the advances on DNA methylation for noninvasive cancer diagnosis.

There are significant differences in average methylation contents and tissue specificity between blood and muscle tissue.

Methylation assay showed that these sequences are heavily methylated in the Fritillaria ussuriensis. Maxim genome.

The team looked at methylation, in which a methyl group is placed onto cytosine in DNA sequences.

A method to determine ginkgolic acids in Ginkgo biloba leaves was developed on the basis of pyrolytic methylation-gas chromatography.

In plants and animals this DNA methylation is species-, tissue-, and organelle-specific.

Inorganic mercury was changed into methyl mercury in fish body through methylation.

In this image, colored bars represent the bases that make up a strand of DNA, while the green circles represent methylation.

The expression of RIZ1 mRNA was found to be lower in the acute myeloid leukemia samples with RIZ1 promoter methylation.

Methylation of cytosine in the 5 position of the pyrimidine ring is a major modification of the DNA in most organisms.

And in rats, such methylation makes young animals especially sensitive to stress, and also fearful of novelty.

Methylation within the NF2 promoter region was only identified at a single CpG site in one tumor sample.

The relationship between levels of DNA methylation and gene activity has been known for some time.

DNA methylation is a frequent change in epigenetics of leukemia.

Each core histone exists in different variants partly as a result of posttranslational modifications such as methylation.

The ability to track methylation is thus scientifically important.

It attempts to store all data about DNA methylation in a common source.

Some methods could also determine the pattern of methylation or the degree of pectins acetylation.

It take for S-adenosylmethionine as methyl donor. DNA methylation has essential roles in many plant life processes.

Can altered methylation patterns be somehow detected in blood samples?

DNA methylation is one of the modification ways which exist in all kinds of organisms widely.

GSK-3 inhibits PP2A activity partially by regulation post-translational modifications of phosphorylation and methylation.

They found 88 sites on the men's DNA where the amount of methylation correlated with their ages.

Histone lysine methylation plays a key role in epigenetic regulation.

"DNA methylation in the kidney is different from DNA methylation in the liver, " he says.

DNA methylation is a common event in malignances and implicated in tumor initiation and progression.

Each step involves a chemical process called methylation.

Here is to summarize the research progress of DNA methylation in colorectal cancer.

A model of methylation-regulated DNA replication is proposed.

Compared to the control, 14 sites showed denovo methylation, and 22 sites were demethylated in the samples after cryopreservation.

Alterations in DNA methylation, an important regulator of gene transcription, lead to cancer.

Methylation analysis showed there were different levels of methylation in Zizania latifolia, but high level of methylation in rice.

The results indicated that the methylation level of some genes changed during hybrid stability.

The methylation of glycol monophenyl ether catalyzed with ZPBBC was also discussed.

This article review the relationship among methylation of DNA with gastr. . .

DNA methylation plays a key role in transgene silencing.

Using strain C514 as experimental strain, the factors that influenced C5-O methylation of avermectins were studied.

Because the variation of methylation's pattern in plant can usually transmit for descendants through miosis.

Cytosine methylation silences transposable elements in plants, vertebrates, and fungi but also regulates gene expression.

This constantly growing data base has become a key resource in the field of DNA methylation research.

Epigenetic alterations, such as abnormal DNA-methylation patterns, are associated with many human tumour types.

Matthew Simon, a postdoctoral fellow in Shokat's laboratory, produced pure samples of H3 and H4 histones with the desired methylation marks.

DNA methylation, amongst the known epigenetic modi? cations, appears to play a crucial role in leukaemogenesis.

Epigenetic processes, such as DNA methylation, are known to regulate tissue specific gene expression.

DNA methylation is a kind of normal endogenous modified mode, which is fulfilled by DNA methylation transferase.

But the patterns of methylation change as we grow older. Which was a clue that measuring methylation might give away age.

Methylation typically silences genes so that they are not expressed.

DNA methylation is attracting more and more attention in the research of tumor and its diagnosis and cure.

But the patterns of methylation change as we grow older.

This is the first report on the methylation patterns of in vitro-derived mouse tetraploid embryos.

We further show that CTCF binding to CD45 exon 5 is inhibited by DNA methylation, leading to reciprocal effects on exon 5 inclusion.

Results The methylation of p16 and DAPK gene promoter was not detected in 30 normal gastric biopsy tissues.

DNA methylation was also measured at days 15 and 29 after the first treatment cycle.

The mutations were classified into 10 types, including 3 increased types of methylation-degree, 3 decreased types and 4 undecided types.

Because of the reversibility of methylation, the drugs reducing the level of methylation become a new way to cure leukemia.

Conclusion: 1. the expression of SP17 is enhanced by low methylation status2.

Methylation plays a part in many critical cellular functions.

In this paper, the methylation of 2-MN to 2, 6-dimethylnaphthalene(2, 6-DMN) over zeolite catalysts was studied.

On the other hand, genome methylation can control hormonal signal.

RASSF1A promoter methylation rate in rectum cancer was higher than that in the colon cancer (P05).

DNA sequencing, which is rapidly dropping in price, can also be used to study DNA methylation.

A specific methylation pattern of the E-cadherin gene promoter is associated with its expression in prostate cancer lines

Study of relationship between arsenic methylation and skin lesion in a population with long-term high arsenic exposure

Relationship between Methylation State of the ANF Gene and its Expression and Regulation

Clinical meaning of detecting CPG methylation around the promoter region of E-cadherin of gastric carcinoma by MSP

Homocysteine-mediated Aberrant DNA Methylation in Vascular Smooth Muscle Cells and Its Potential Pathogenic Mechanism

Relation between promoter methylation of E-cadherin gene and gastric and colorectal adenocarcinoma and its significance

Radiation-induced DNA methylation profile changes and its impact on mechanisms of radiation carcinogenesis

Identification of Synthetic Adhesives by Simultaneous Pyrolysis Methylation Gas Chromatography

Scanning the Differential Methylation Sequences in Hepatocellular Carcinoma Cell Line by Subtractive Hybridization

Application of Simultaneous Pyrolysis Methylation Gas Chromatography to the Identification of Paint Varieties

Expression of the FHIT Gene in Human Cervical Carcinoma Cell Lines and Its Regulation by Methylation

Effect of Deacetylation in Course of Konjac Glucomannan Carboxy Methylation and Structure Characterization of the Products

A relationship between the methylation of epithelial cadherin gene and biological behaviour of lung cancer

Clinicopathological significance of aberrant methylation of the fragile histidine triad gene in patients with hepatocellular carcinoma

Fragile histidine triad gene aberrant methylation and its expression in gastric carcinoma

Analysis of Genomic DNA Methylation Level in Radish under Cadmium Stress by Methylation-sensitive Amplified Polymorphism Technique

Conclusions: The HPLC method that we have established for assaying the genome-wide DNA total methylation level is stable and reproducible;

Pilot Study on the Pressurized Sulfonation and Methylation Technique of Utilizing Black Liquor to Prepare Additive for Coal Water Slurry

Many studies have explored the mosaic patterns of DNA methylation and histone modification in cancer cells on a gene-by-gene basis;

Studying the Expression of PTEN and Its CpG Island Methylation Status in Gastric Carcinoma Cells

Aberrant methylation of CpG islands in thrombospondin 1 gene and its clinical significance in gastric adenocarcinoma

Product Petrol of High Benefit though Catalyzed Rectification. New Breakthrough of Sulfuric Acid Methylation

Analysis of the methylation in CpG island by denaturing high-performance liquid chromatography

Preparation and Characterization of Ti-Si Mixed Oxides and Their Catalytic Activities for Vapour-phase O-Methylation of Catechol

Relationship between E-cadherin gene methylation and clinicopathological characteristics of colorectal cancer

Improvement of the preparation method for carboxy methylation of konjac glucomannan

Promoter methylation of ER gene and clinicopathologic features in hepatocellular carcinoma

Correlation between methylation status of tumor - related genes and mRNA transcriptional level in lung cancer cell lines

Relationship between Individual DNA Methylation Percentage Difference and Carcass Traits in Pig

Relationship between the Pattern of Methylation of Calcitonin Gene and Activity of Methyltransferase in 8 Tumor Cell Lines

Improvement and Application of Methylation-specific Polymerase Chain Reaction

Clinical application of tumor suppressor genes methylation detection in colorectal cancer

The relationship between tumorigenesis and its cure and DNA methylation

Preparation and Characterization of AlPxO Catalysts and Their Catalytic Properties for the Vapour-phase O-Methylation of Catechol

Effect of spleen tyrosine kinase expression re-activation by inhibition of DNA methylation on oncogenesis growth of gastric cancer

Study on Determination of Toxic Iso-Nitrophenol Derivatives by Gas Chromatography with Methylation

Advances in the methylation profiles of hepatocellular carcinomas associated genes

Determination of DNA Methylation Contents Both in the Blood and Muscle Tissue of Pigs and Significant Difference Analysis

The antioxidative vitamins reduce atherosclerosis and protect DNA methylation of high-fat diet rabbits

[Romain Barres et al. , "Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle" ]

Binders for paints and varnishes - Methylation and silylation of fatty acids and analysis by gas chromatography

Aberrant methylation of FHIT gene and its expression in gastric carcinoma

Tumor Suppressor Genes Promoter Methylation in Elderly Patients with Gastric Carcinoma

Relationship between DNA methylation and esophageal carcinoma

The influence on clinical values by optimizing the annealing-temperature of methylation specific PCR

Transcriptional Expression and Promoter methylation of FHIT gene in Lung Carcinoma Tissues and Cell

Regulation of DNA methylation on the expression of tumor suppressor gene and oncogene in human colon cancer cell lines

Relation of methylation of plasma thrombomodulin gene promoter and coronary heart disease

Stress Treatments and DNA Methylation Affected the Somatic Embryogenesis of Citrus Callus

Analysis of methylation profiles of APC gene promotor in lung cancer by methylation-specific microarray

Role of DNA methylation in control of tumor suppressor gene and oncogene expression in colorectal carcinoma

The mechanism of DNA abnormal methylation and its effect on carcinogenesis

Research on the Relationship between Methylation of E-cadherin and the Clinicopathological Features of Hepatocellular Carcinoma

The Method to Determine the Global Levels of DNA Methylation in Paulownia Leaves

The Research Progress of Gene Methylation Related to Gastric Cancer and its Precancerous Change

Molecular Mechanism of Plant Flowering Regulated by Histone Methylation

The Discussing of the Condition Synthesize AEC in Carboxy Methylation

Density Functional Theory on Dimethyl Carbonate as Methylation Reagent

DNA Methylation, Histone Modifications and Genes Silencing

this pattern of methylation does not require extensive

Patterns of DNA Cytosine Methylation between Hybrids and Their Parents in Sorghum Genome

The mutation and abnormal methylation of VHL tumor-suppressor gene in primary renal cell carcinoma

Biological Implications of DNA Methylation and DNA Methylation Assays

Role of multiple genes methylation in pancreatic carcinogenesis

Relationship between DNA methylation aberration and human tumor

Influencing factors for high amylose carboxyl-methylation

The relationship between DNA methylation and tumour generation and therapy

The Progress about DNA Methylation and its Role In Cervical Cancer

Deletion of OPCML Gene and Promoter Methylation in Ovarian Epithelial Carcinoma

DNA Methylation in Plants and Its Epigenetic Function

methylation specificpolymerase chain reaction, PCR

Methylation of promoter and expression of FHIT gene in laryngeal squamous cell carcinoma

Significance of Methylation of the ASC Gene Promoter in Non-small Cell Lung Cancers

Expression and methylation of tumor-associated genes in human gastric cancer cell lines

Progress in the Studies of DNA Methylation and Transgenes Silencing in Transgenic Plants

Promoter methylation profile of androgen receptor gene in leukemic cells

Dense methylation at all Cs is observed in sequences

Quality control of the procedure of methylation-specific PCR

Changes of DNA methylation during differentiation of human glioma cells induced by NDGA

The Promoter Methylation Status of E-cadherin Gene in Plasma Cervical Cancer Patients

Regulation of tumor suppressor gene methylation in human gastric cancer

Effect of aberrant DNA methylation on the expression of cancer-related genes in Cd-transformed cells

Applications of DNA Methylation Markers in Forensic Medicine

The heavy methylation incurred by nonsymmetrical

The Relationship of DNA Methylation and Histone Methylation

The roles of histone lysine methylation in epigenetic regulation

Aberrant DNA Methylation and Histone Modification in Tumor

Aberrant DNA Methylation and Tumor Invasion and Metastasis

Relationship between status of DNA methylation and folic acid in gastric precancerosis lesions

Review and evaluation of methodology of research on DNA methylation

Prospects of DNA Methylation and Molecular Diagnosis of Tumors

Development of Histone Methylation and Demethylation

Research Progress of Histone Methylation

Effects of DNA Methylation Difference Growth Traits

Methylation of BLU gene in hepatocellular carcinoma

Analysis of CpG island methylation status of E-cadherin gene in bladder cancer

Detection of multiple gene methylation in gastric cancer

A Study on the Methylation of Related Genes in Gastric Carcinogenesis

The epigenetics of histone lysine methylation