A new process has been developed to synthesize dimethoxy methyl acetoacetate with dimethoxyacetic acid methyl ester and methyl acetate in the presence of sodium methanol.
以二甲氧基乙酸甲酷和乙酸甲酷为主要原料，经甲醇钠催化制备二甲氧基乙酞乙酸甲醋。
2
Cefixime open side chain acid was prepared by oximation, etherification, chlorination, ester decomposition using t-butyl acetoacetate as starting material.