tamoxifen

Tamoxifen is still a useful drug, although newer drugs called aromatase inhibitors seem to work better in clinical trials.

Tamoxifen, a drug that blocks the effects of estrogen on the body, is often used to treat women whose tumors are sensitive to estrogen.

Prior to this study, tamoxifen was used for the treatment and prevention of oestrogen receptor-positive breast cancers, Dr. Pinkerton said.

Gynecomastia can be painful and feel tender. This can be treated with medications like the antiestrogen drug tamoxifen.

They discovered that when cancer cells are fed tamoxifen, they sometimes respond by elevating expression of a gene known as AKT.

Now it appears that some women will do at least as well if they're treated with tamoxifen.

Tamoxifen is usually given to women with oestrogen-sensitive breast cancer.

Unlike tamoxifen, aromatase inhibitors do not cause menopausal symptoms, but they may increase risk of osteoporosis.

abstract: Objective: To investigate the side with self consumption addiction treatment tamoxifen clinical efficacy of mammary glands.

It has a more favorable toxicity profile than tamoxifen and provides an alternative for postmenopausal women.

Conclusion Tamoxifen can inhibit SHG-44 glioma cells proliferation. The inhibion of sodium channel may be one of its mechanisms.

The team also found that giving tamoxifen after chemotherapy ended instead of during chemotherapy improved a woman's survival chances.

For women with the gene variant linked to poor response to tamoxifen treatment, other treatment strategies would be a better choice.

This observation has not been confirmed by other trials employing long term tamoxifen treatment.

We investigated whether letrozole monotherapy prolonged overall survival (OS) compared with tamoxifen monotherapy.

The researchers suggest that genetic testing could identify women who should not be treated with tamoxifen.

Presentation title: Tamoxifen Adherence and Its Relationship to Mortality in Women With Breast Cancer.

Tamoxifen can induce or exacerbate menopausal symptoms but reduces incidence of contralateral breast cancer and lowers serum cholesterol.

The aim of this study was to investigate the prognostic and tamoxifen predictive values of 17HSD1 and 17HSD2 expression.

The research suggests that some antidepressants hinder the action of an enzyme that's key to tamoxifen's functioning.

Tamoxifen, which cancels out the sex hormone oestrogen, was first used to fight breast cancer more than 40 years ago.

About 500, 000 women in the United States take tamoxifen, which cuts in half the chances of a breast cancer recurrence.

Letrozole may be used for postmenopausal women who have completed 5 yr of daily tamoxifen.

Up until this trial, studies adding common chemotherapy drugs to tamoxifen or tamoxifen alone were essentially negative.

Tamoxifen antagonized effect of estradiol, suggested that estradiol inhibited neointimal proliferation by estrogen receptor.

Despite this risk, tamoxifen and another drug in this class, raloxifene, remain an extensively used and popular treatment.

Objective: To investigate effect of tamoxifen on estradiol inhibition neointimal proliferation after rats carotid common arteries injury.

Tamoxifen can result in serious side effects including blood clots, strokes, uterine cancer and cataracts.

Doctors have long known that some antidepressants and other medicines can lower the amount of tamoxifen's active form in the bloodstream.

Objective. To evaluate the effects of Tamoxifen (TMX) and trifluoperazine (TFP) on pinealectomized chicken scoliosis.

It is reported that Tamoxifen Citrate as estrogen receptor antagonist, has a certain therapeutic effect on vascular tumors.

Objective To observe the antioxidant activity of Tamoxifen(TAM) on human breast cancer cells in vitro.

Until these data are absolutely clear, I would avoid drugs that impact on tamoxifen metabolism.

Such women carry a version of a gene called CYP2D6 that makes tamoxifen work better.

Aromatase inhibitors, a newer class of drugs, cause fewer problems than tamoxifen.

Tamoxifen improves bone density in postmenopausal women, and there is some evidence of fracture reduction.

Cancer has been around longer and drugs like tamoxifen for breast cancer don't have to cost a packet.

Some experts combine ovarian ablation with tamoxifen therapy.

Objective To observe the curative effects of Rukuaixiao capsule and Tamoxifen(TAM) for cyclomastopathy.

A single gene variant predicts breast cancer survival after tamoxifen treatment, a new study finds.

She now takes Tamoxifen, an estrogen-blocking pill, to reduce her risk of recurrence.

Prof Evans is leading a study into the use of the drug tamoxifen, which may reduce the risk of breast cancer by 40 per cent.

Objective To explore the effects of tamoxifen on the proliferation of SHG-44 glioma cells and the currents of sodium channel.

Tamoxifen at a dose of 20 mg once daily is recommended for 5 years to decrease the risk of breast cancer recurrence and mortality.

'This is simply a situation in which [Seroxat] impairs the effectiveness of tamoxifen, ' they said.

One promising study compared acetyl-L-carnitine to tamoxifen in 48 men with this condition.

In the 46% of women with the "good" gene, tamoxifen works as well as newer drugs.

In the tamoxifen group, five patients (3%) had a complete response, and 52 (17%) had a partial response.

Giving the same cells tamoxifen at the same time dramatically curtails the ability of the cells to proliferate.

Women who had used antidepressants in the year before starting tamoxifen were also more likely to quit (HR 1. 41).

The study also showed that increased duration of tamoxifen use was associated with improved survival.

However, tamoxifen is associated with increased risk of death from other causes, such as strokes and endometrial cancer.

In fact, for women who were followed for 5 years or more, adherence with tamoxifen therapy was modest (49%).

The uptake of TMCN and tamoxifen by MCF-7 was estimated from the intracellular iron concentration.

Of the 2, 080 women in the entire cohort, 1, 633 (79%) had been prescribed tamoxifen as adjuvant therapy.

Ask your doctor whether you should take a cancer risk-reducing agent such as tamoxifen.

Median duration of tamoxifen use was 2. 42 years.

The study did exclude women who began a different hormonal therapy within 6 months of stopping tamoxifen (25. 4%).

An Experimental Study of the Inhibition of Tamoxifen on Rat Model of Benign Prostatic Hyperplasia

Tamoxifen may reduce cardiovascular mortality risk. However, it significantly increases risk of developing endometrial cancer;

Effects of tamoxifen on volume-activated Cl- currents of nasopharyngeal carcinoma cells at different stages of the cell cycle

Effect of tamoxifen on the immediate stretch-back rate of the expanded skin and the histopathology of fibrous capsule

Clinical observation of chemotherapy combined with tamoxifen in treatment of patients with pulmonary carcinoma

One year observation on effects of estrogen, tamoxifen combined with or without fluoride on preventing bone loss in ovariectomized rats

Bioequivalence of sustained - release tamoxifen citrate tablets in healthy volunteers

Study of Chemotherapy with Tamoxifen for Treatment of Non-small Cell Lung Cancer

Tamoxifen Modulates the Expression of Complement Inhibitory Proteins on Chorio-carcinoma Cell Line JAR

An experimental study on the effect of somatostatin in antagonizing the maladjustment of sexual hormones homeostasis induced by tamoxifen

Apoptosis of LoVo colon cancer cells induced by tamoxifen and its mechanism

Influence of tamoxifen on bone mineral density of cancellated bone and compact bone in ovariectomized rats

Investigation of hyperplasia of mammary glands treated with combination of Shuganxiaopi decoction and Tamoxifen

Effects of Tamoxifen on Expression of Oestrogen Receptors, Progesterone Receptors and Ki-67 in Postmenopausal Endometrium

Development of sustained release tablet of tamoxifen citrate and its in vitro release profile

Experimental Study on Rat Model of Endometriosis Treated with Tamoxifen and Rhizoma Curcumae Oil

Effects of tamoxifen on transplanted human hepatocellular carcinoma in nude mice

Irradiation may not be necessary in women receiving tamoxifen

Effect of different dosage of tamoxifen on the morphology of the mammary hyperplasia of rats

Studies of the effect and mechanism of tamoxifen on the proliferation of human pancreatic cancer cell lines

Experimental study on the effect of different dosage of tamoxifen on the estrogen receptor and progesterone receptor status in rats

Endocrine Changes in postmenopausal Women Using Tamoxifen

Effects of tamoxifen on biomechanical properties of bone in ovariectomized rats

The Exploration of the Effect of Estrogen and Progesterone Receptors in Gastric Cancer and the Treatment of Tamoxifen

The influence of tamoxifen ointments on hypertrophic scar fibroblast

Studies of the Effect and Mechanism of Tamoxifen on the Proliferation of Human Colonic Cancer Cell Lines

Inhibitory effect of tamoxifen on DNA and collagen syntheses of hypertrophic sc ar fibroblasts in vitro

Pathomorphologic Study of the Viscera of Mice under the Influence of Tamoxifen

Effect of tamoxifen on estradiol inhibition neointimal proliferation after arterial injury

Effect of Different Dosage of Tamoxifen on Mammary Hyperplasia and Angiogenesis in Rats

Reversing effect on multidrug resistance in refractory and relapsed acute leukemias by cyclosporin A and tamoxifen

Reversal of Multi-drug Resistance by Tamoxifen in Ovarian Carcinoma Cells

High dose tamoxifen in the reversal treatment of multidrug resistance to EP regimen in patients with non-small cell lung cancer

Tamoxifen Lowers Risk of Cardiovascular Disease

Clinical Analysis of Rupixiao Combined with Tamoxifen in the Treatment of Mammary Gland Hyperplasia

Effects of tamoxifen and estradiol on neointimal proliferation after balloon injury of rat artery

Study on Pharmacodynamics of High-Dose Tamoxifen in NSCLC Patients

Reversal of adraimycin-resistance in ovarian carcinoma cells by verapamil and tamoxifen in vitro

Graphical Synthetic Routes of Tamoxifen

Tamoxifen inhibits the growth of ER negative thyroid carcinomas in vitro and in vivo

Experimental Study on Treatment of Non-Small Cell Lung Cancer by Estrogen Antagonists, Tamoxifen and 4-hydroxytamoxifen

The Curative Effects of Tamoxifen on 136 Cases of Precancerous Mammary Diseases

A study on the expression of estrogen receptor and the effect of Tamoxifen treatment in lung cancer

Inhibitory effect of tamoxifen on colon cancer cell lines

Effect of Tamoxifen on interstitial fibrosis in UUO rats

The effects of tamoxifen on the endometrium

Effects of tamoxifen in human glioma cells

The effects of tamoxifen on multidrug resistance of colon cancer in vivo