P450

The present drug2013drug interaction can be attributed to a strong inhibitory effect on cytochrome P450-3A4 activity by voriconazole.

The Cytochrome P450 superfamily participated in at least 16 key enzyme reactions in phenylpropanoid pathway.

METHODS The ultraviolet spectrophotometric method was used to measure P450 concentration of hepatic microsomes.

This included characterization of an enzyme, cytochrome P450, that always introduces the epoxide in the desired beta configuration.

This review provides a better understanding of the cytochrome P450 system with a focus on those enzymes most involved in drug metabolism.

Azole and triazole drugs are cytochrome P450 inhibitors widely used as fungal antibiotics and possessing potent antimycobacterial activity.

Compound lipophilicity is of key importance to P450 binding affinity and enzyme selectivity.

OBJECTIVE To introduce the research status of cytochrome P450 and its new applications in clinical pharmacy.

Objective: To investigate the expression of the aromatase P450 in breast hypertrophy and discuss its significance.

An example of a flavoprotein undergoing a one-electron transfer is with the microsomal NADPH-cytochrome P450 reductase.

Objective To observe the role of aromatase cytochrome P450 in the pathogenesis of endometrial hyperplasia and endometrial cancer.

Yeast does have endogenous microsomal cytochrome P450 enzymes and energy supporting systems, what is a major advantage for this host system.

OBJECTIVE To investigate the protective effects that phenobarbital sodium(Phe) induces cytochrome P450 (P450) against endotoxin (End).

Clopidogrel is metabolically activated by several hepatic cytochrome P450 (CYP) isoenzymes, including CYP1A2.

Cytochrome P450 enzymes are very important for metabolism function in body.

Furthermore, log P values for P450 substrates appear to represent markers for enzyme selectivity.

The progress on the relationship between cytochrome P450 and drug-induced liver injury was reviewed.

Conclusion The positive expression of aromatase P450 in cervical cancer tissues is related to the genesis of cervical carcinoma.

Cytochrome P450s are a large group of heme-binding enzymes and widely distribute in biology.

Aim To investigate the influence of cytochrome P450 CYP2C9 polymorphism on the pharmacokinetics of tolbutamide.

The identified PLA1 gene encodes a cytochrome P450, CYP78A11, which potentially catalyzes substances controlling plant development.

The cloning strategies and identification methods of plant cytochrome P450s were summarized. And the future researches were predicted.

Our results probably shed a light on studies of P450 genes in rice defense and development.

Cytochrome P450 enzyme are an important enzyme family in drug metabolism.

P450 genes are widely involved in development and defense of plants.

Epilepsy is a common disease in nervous system. Most antiepileptic drugs are metabolized by liver enzymes. such as cytochrome P450 enzyme.

Here, lipophilicity is discussed with reference to the human drug-metabolizing P450 enzymes of families CYP1, CYP2 and CYP3.

ObjectiveTo introduce the effect of chemical constituents from Chinese herbal medicine on CYP3A4 isoform of cytochrome P450 system.

Cytochrome P450 (CYP450) is the crucial metabolizing enzymes in the bodies. It is the most important effect for drug metabolization.

In recent years, researches found that there were many kinds of cytochrome P450 enzymes which related to multidrug resistance of tumor.

Objective: To study the effects of trans-resveratrol and trans-piceid on liver weight, contents of microsomal protein and cytochrome P450.

Effects of tobacco smoke exposure in pregnancy on maternal hepatic and placental cytochrome P-450 isozymes expression in rats