In the 1960s, M. leprae started to develop resistance to dapsone, the world’s only known anti-leprosy drug at that time.
在1960年代，麻风杆菌开始对世界上当时唯一已知的抗麻风药物氨苯砜形成抗药性。
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Objective: To detect resistant stains of Mycobacterium leprae to dapsone (DDS) and rifampicin (RFP) and to understand the relationship between relapse and drug resistance.