Damage to the central nervous system (CNS) is always followed by an irreversible axon degeneration of injured neurons.
成年哺乳动物中枢神经系统(CNS)损伤，常导致神经元死亡及轴突不可逆的退化。
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Objective To localize the functional involvement of the central nervous system (CNS) in patients with subacute combined degeneration (SCD).
目的探讨亚急性联合变性（SCD）患者中枢神经系统（CNS）功能受累的部位。
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Conclusion IGF-1 system was involved in the pathogenic mechanism of MND, the lack of neurotrophic support might be one of causes in leading to degeneration of spinal motor neurons.