This paper studied some of the highlights in the progress of the research of carbapenem antibiotics, designed and mainly synthesized branched chain intermediate of biapenem.

E. coli showed low drug resistance ratio to carbapenem, cephamycins, amikacin and furadantin, and Klebsiella pneumoniae showed a good sensitivity to most of the antibiotics.

And most of them show severe drug resistance to antibiotics, and the resistant rate to carbapenem is high.