The ACCP guidelines do not support the use of aspirin for prophylaxis following TJA, because this drug has not been extensively evaluated in multicenter randomized trials.

Phase III studies are multicenter trials on large patient groups designed to be the definitive assessment of a drug's effectiveness.

There is clearly a need for prospective, multicenter, large-scale trials to aid surgical decision-making in the future regarding the treatment of distal humeral fractures.