腺苷
Forskolin (1.0μmol/L), a directly activator of adenylyl cyclase stronglyinhibited ANP secretion (p＜0.01)concomitantly with increased in atrial strokevolume and cAMP efflux (p＜0.01), as well in a certain range the more production of cAMP the more inhibition of ANP secretion, and therelationship between cAMP production and ANP secretion showed inverseratio (Y=-5.268 X+9.506, r~2=0.971, P＜0.001).7.
6．腺苷酸环化酶的直接激活剂forskolin(1.0μmol／L)明显抑制ANP分泌(p＜0.01)的同时显著增加心房搏出量(p＜0.01)和cAMP逸出量(p＜0.01)，且在一定范围内，cAMP的生成与ANP分泌的抑制效应呈负相关(Y=-5.268 X+9.506，r~2=0.971，p＜0.001)。