Objective To investigate the action of recombinant protein of tissue inhibitor of metalloproteinase-3(TIMP-3)on apoptosis of MC3T3-E1 osteoblasts.
目的研究组织金属蛋白酶抑制因子3（TIMP-3）重组蛋白对MC3T3-E1成骨细胞凋亡的影响。
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Conclusions The abnormal expressions of MMP? 1, 2, 3 and TIMP? 1, 2, which resulted in degradation disorder of extracellular matrix, could induce degeneration of cartilage.