Abnormality of chromosome behavior occurs from premeiotic mitosis until various stages in meiosis.
从减数分裂前有丝分裂到减数分裂的各个阶段，染色体行为都会发生异常。
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The engineered mice validate the human chromosomeabnormality as one cause of the disease, the researchers said. They will also serve as an invaluable tool for therapeutic development.