Objective To study the synthetic method of pranoprofen. Methods Pranoprofen was synthesized from 2-chloronicotinic acid by condensation, reduction, substitution and acylation.
目的探讨改进合成普拉洛芬的方法方法以2-氯烟酸原料经缩合、还原、取代、酰化等制得普拉洛芬。
2
Conclusion: the HPLC method showed a sensitive, accurate, reproducible and can be effective in the determination content of preservatives benzalkonium chloride in Pranoprofen eye drops.