ZYFF can inhibit auricular swelling caused by xylene in mice and remarkably reduce the phlogistic exudation of granuloma induced by croton oil in rats.

The suppression to the granuloma induced by croton oil and paw edema of adjuvant-induced polyarthritis in rats were utilized to verify the inhibition to the chronic inflammation.

METHOD Acetic acid was used to increase the permeability of mice abdomen capillaries and croton oil was used to make mice external ear swelling model.