In the picoline pyrolysis experiment, the methyl disengages from aromatic ring to form methane firstly, then the following reaction of the aromatic ring is similar to pyridine.
甲基吡啶的热稳定性比吡啶差，热解时甲基首先脱离芳香环进入气相，随后芳香环的反应途径和吡啶类似；
2
4-cyanopyridine, intermediate of rimifon, was synthesized from 4-picoline using vanadium oxide as a catalyst in a fixed-bed reactor, reached 99% conversion of 4-picoline, 88% selectivity and 87.