In general, the initial dose depends on the volume of distribution, and maintenance doses depend on clearance.
一般而言，表观分布容积决定初始剂量，总清除率决定维持剂量。
2
Those assigned to clopidogrel received a 300-mg loading dose before PCI, followed by a maintenancedose of 75 mg daily.
被安排给予氯吡格雷的患者，在PCI前的负载量为300mg，之后的维持剂量为每天75mg。
3
By following these simple maintenance steps you will go a long-way towards extending the life of your housing and preventing a lethal dose of this deadly disease.