These gene mutation distributing in all over the whole coding section of ATM gene. Every Exon exist the gene mutatedsite and no obvious hot mutatedsite be discovered.
这些突变分布于atm基因整个编码区，每个外显子都存在基因变异位点，没有发现明显的突变热点。
2
Methods The polyadenylation signal-deficient retrovirus vector mutated by PCR site-directed mutagenesis was used to make polyadenylation signal-deficient retroviruses by PA317 packaging cells.