To study the feasibility of poloxamer407(P407)gel for intrahepatic injection and to know the dynamic changes of P407 gel in liver.
目的探讨泊洛沙姆407凝胶肝内注射的可行性,了解其肝内注射后的动态变化。
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METHODS Ribavirin was selected as a model drug and the 17.7% poloxamer407 was selected as the base meteral to develop a kind of in situ thermosensitive gels for ophthalmic use.