Objective To solve the problem of non-inferiority test by adjusting central effect in multicentertrials.
目的解决校正中心效应的非劣性检验的问题。
2
Phase III studies are multicentertrials on large patient groups designed to be the definitive assessment of a drug's effectiveness.
三期研究是为最终评估药物有效性而在大批病人中进行的试验。
3
Benefit relative to placebo has been demonstrated in two large multicentertrials, with low doses (100 or 150 mg) having been shown to have therapeutic efficacy.