I looked at my wife in despair.

我绝望地看着妻子。

...feelings of despair or inadequacy.

绝望或无能的感觉

'Oh, I despair sometimes,' he says in mock sorrow. [VERB]

“啊，我有时会感到绝望，”他假装悲伤地说。

He does despair at much of the press criticism. [VERB + at]

面对媒体的诸多批评他的确感到绝望。

He wished to earn a living through writing but despaired of doing so. [VERB + of]

他想通过写作来谋生，不过他对此不抱希望。

...efforts to find homes for people despairing of ever having a roof over their heads. [V of -ing/n]

为那些对有瓦遮头不再抱有任何希望的人们找到住处的努力

There are signs that many voters have already despaired of politicians. [V of -ing/n]

有迹象表明许多选民对政客已经不抱希望。