霍夫曼、麦哲托夫和比尤特勒三位科学家的关键性研究，为先天性免疫系统的病原体识别/反应模式奠定原理。 shawprize.org | These three scientists, Hoffmann, Medzhitov and Beutler, through their critical work, laid out the principles underlying the pathogen recognition/ response model of the innate immune system. shawprize.org |
在进一步的研究中，比尤特勒采用正向遗传学策略阐释多方面有关哺乳动物的免疫力。 shawprize.org | In further studies, Beutler employed a forward genetic strategy to elucidate many aspects of mammalian immunity. shawprize.org |
(左起) JCEP个案服务主任蔡韵龄小姐及陈诗韵小姐分享她们提供早期干预服务的经验及感受。 xn--pssu7cv61a...xn--wcvs22d.hk | (From left) JCEP Case Intervention Officers Ms Ranee Choi and Ms Peggy Chan share their experience on executing the early intervention service. xn--pssu7cv61a...xn--wcvs22d.hk |
(左起) 赛马会思觉健康计划（JCEP）个案服务主任蔡韵龄小姐及陈诗韵小姐、赛马会思觉健康计划研究总主任许丽明博士、香港大学李嘉诚医学院精神医学系教授兼赛马会思觉健康计划总监陈友凯教授以及赛马会思觉健康计划行政总主任谭蕴怡小姐介绍有关针对思觉失调患的早期干预治疗成效研究结果。 xn--pssu7cv61a...xn--wcvs22d.hk | (From left) Ms Ranee Choi and Ms Peggy Chan, Jockey Club Early Psychosis Project (JCEP) Case Intervention Officers; Dr. Christy HUI Lai-ming, JCEP Chief Research Officer; Professor Eric CHEN Yu-hai, JCEP Project Director and Professor, Department of Psychiatry, The University of Hong Kong Li Ka Shing Faculty of Medicine and Ms Wendy TAM, JCEP Chief Administrative Officer, introduce the study results of the impacts of early intervention treatment on early psychosis patients. xn--pssu7cv61a...xn--wcvs22d.hk |
1990年代初，要确定哪一个基因是突变体是非常艰巨的工作，但比尤特勒努力不懈，进行了精确的实验，确认了那个突变的基因，证实它正正就是麦哲托夫和简韦在人类基因数据库内找到的基因。 shawprize.org | Identifying which gene was mutant was a daunting task in the early 1990s when Beutler undertook these studies but he persevered and, through elegant experiments, showed that the mutant gene was precisely the TLR that Medzhitov and Janeway had identified in the human database, a gene now known as TLR4. shawprize.org |
这个基因现在名为 TLR4。比尤特勒的研究指出，TLR 在生理上是人类及其他嵴椎动物的先天性免疫系统的重要活化剂，亦确定了一种已知的先天性免疫系统细菌活化剂 LPS 是由 TLR4 识别到的。 shawprize.org | Beutler’s work showed that TLRs were physiologically important activators of the innate immune system of humans and other vertebrates and established that a known bacterial activator of the innate immune system, LPS, was recognized by TLR4. shawprize.org |