| 单词 | 阿尔茨海默病 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 释义 | 阿尔茨海默病 —Alzheimer's diseaseless common: senile dementia 阿尔茨海默 —Alois Alzheimer (1864-1915), German psychiatrist and |
此前FDA已批准了数种用于治疗轻度 阿尔茨海默病 的 药物，多为胆碱酯酶抑制剂，但都未能从根本上治愈，且基本上是针对中早期患者。 chinese.eurekalert.org | USA. Food and Drug Administration has previously [...] approved many drugs for the treatment [...] of mild Alzheimer's disease, most of which belong [...]to cholinesterase inhibitors and [...]have failed to fundamentally cure. chinese.eurekalert.org |
位于尿激酶型纤溶酶原激活剂基因第6外显子rs2227564位点的C/T错义多态性被认为是可能 与阿尔茨海默病 发 病相关的热议位点。 chinese.eurekalert.org | A missense C/T polymorphism in exon 6 [...] (the NCBI rsID is rs2227564) of the urokinase-type plasminogen activator gene has been identified as a possible hot spot for Alzheimer’s disease risk. chinese.eurekalert.org |
此 外，阿尔茨海默病和其 他失智症导致严重残障，往往对照护人造成重大负担。 daccess-ods.un.org | In addition, Alzheimer’s and other dementias cause profound impairment and often place a severe burden on caregivers. daccess-ods.un.org |
TTP488是首个与RAGE相关的药物，RAGE是阿尔茨海默病 研 究中一个相对较新的生物靶点，多项临床试验已显示治疗获得成功。 sharesinv.com | TTP488 is the first drug related [...] to RAGE, a relatively new biological [...] target in Alzheimer’s disease research, with demonstrated [...]success in multiple clinical trials. sharesinv.com |
有研究表明，脑源性神经营养因子与学习记忆能力密切相关， 在阿尔茨海默病 神 经 元的修复及结构重建中起着重要作用。 chinese.eurekalert.org | Brain-derived neurotrophic factor is associated with [...] learning and memory ability and plays an important role in the repair and [...] reconstruction of neurons in Alzheimer’s disease. chinese.eurekalert.org |
政府的应对措施注重各种问题，包括药 品补贴、免除使用费、医疗保险计划、特殊服务，包括专门针对老人的部门，专 [...] 注一些慢性疾病、人员培训以及研究和政策，以应对心理健康问题，特别是老年 痴呆症，尤其是阿尔茨海默病。 daccess-ods.un.org | Government responses have focused on various issues, including subsidies for medicines, user fee exemptions, health insurance schemes, special services, including geriatricspecific departments, focused attention on certain chronic diseases, training of [...] personnel and research and policies to address mental health issues, notably dementia and, [...] specifically, Alzheimer’s disease. daccess-ods.un.org |
目前认为，阿尔茨海默病患者脑细胞内存在的过量淀粉样β肽与淀粉样β肽相关乙醇脱氢酶结合，干扰了细胞内正常氧化还原过程，导致线粒体肿胀、神经元死亡。 chinese.eurekalert.org | It is now considered binding of [...] excessive amyloid β peptide (Aβ) to amyloid β peptide [...]binding alcohol dehydrogenase (ABAD) [...]in the brain cells of Alzheimer’s disease patients hinders the normal intracellular redox process, leading to mitochondrial swelling and neuronal death. chinese.eurekalert.org |
阿尔茨海默病是最 常见的痴呆形式，是一种进展性的神经退行性障碍，引起认知和功能减退。 sharesinv.com | Alzheimer’s disease, the most common [...] form of dementia, is a progressive neurodegenerative disorder that causes decline in [...]cognition and functional abilities. sharesinv.com |
北卡罗莱纳州HIGH POINT--(美国商业资讯)--TransTech Pharma [...] Inc.今天宣布，美国食品药品管理局(FDA)已核准TTP488进入快速审批通道，该药是一种新的小分子化学化合物，目前正在开发用于治 疗阿尔茨海默病。 sharesinv.com | )--TransTech Pharma Inc. announced today that the U.S. Food and Drug Administration (FDA) has granted Fast Track [...] designation for TTP488, a new small-molecule chemical compound being developed for [...] the treatment of Alzheimer’s disease. sharesinv.com |
当前，阿尔茨海默病主要 是依靠认知能力的改变以及排除其他会导致这些改变的病因后诊断的。 labtestsonline.org.cn | Alzheimer's disease is currently diagnosed based on [...] cognitive changes and by ruling out other causes of these changes. labtestsonline.org |
这一进展体现出TT488有望在成百万上千 万阿尔茨海默病 患 者 的治疗中满足巨大的、未获满足的医疗需求，该病是一种毁灭性的、危及生命的疾病，给我们的老龄人口造成深重的后果。 sharesinv.com | This development reflects a recognition that TT488 has the potential to [...] address huge unmet medical needs for the [...] treatment of millions of patients suffering from Alzheimer’s [...]disease, a devastating and [...]life-threatening disease with profound consequences for our aging population. sharesinv.com |
雌激素与神经细胞中的雌激素受体结合后，可减少淀粉样β蛋白的沉积并拮抗其细胞毒性作用， 对阿尔茨海默病 具 有潜在的治疗作用。 chinese.eurekalert.org | Estrogen binding of estrogen receptors in nerve cells can reduce amyloid β [...] protein deposition and antagonize its cytotoxic [...] effects in Alzheimer’s disease, providing a potential [...]therapeutic effect. chinese.eurekalert.org |
11月22日，CNN /Health.com（Harding）报道，在过去几年中，研究者发现在体重 和阿尔茨海默病 之 间 有这奇特的关系：肥胖的中年人更易 患阿尔茨海默病 ， 而 老年人如果超重风险却更小。 uschie.org | CNN /Health.com (11/22, Harding) reports, "Over the past several years, researchers have noticed an odd pattern in the relationship [...] between body weight [...] and Alzheimer's disease: Middle-aged people have a higher long-term risk of developing the disease if they're overweight or obese, while older people have a lower risk of the disease if they're carrying [...]excess weight. uschie.org |
近期一项双盲临床试验中，18个月期间采集的数据显示，TTP488可延缓轻中 度阿尔茨海默病 患 者 的认知减退。 sharesinv.com | In a recent double-blind clinical trial [...] where data was taken over 18 months, TTP488 slowed cognitive decline in [...] patients with mild to moderate Alzheimer’s disease. sharesinv.com |
美金刚治疗晚期阿尔茨海默病的安 全剂量 chinese.eurekalert.org | Safe dose [...] of memantine for advanced Alzheimer's disease chinese.eurekalert.org |
基本上任何标记物都不会与10倍风险有关，所以确实需要通过另一项研究来再现上述结果，但它告诉我们血浆或血清中的神经酰胺水平 与阿尔茨海默病 风 险 升高有关。 china.labmedica.com | Pretty much any marker is not going to be associated with a 10-fold risk, so yes, this does need to be replicated in another study, but it [...] suggests to us that plasma or blood ceramide levels are associated with an [...] increased risk of Alzheimer's disease," she said. labmedica.com |
更严重的损害可能指向老年痴呆症和 阿尔茨海默 氏 病 ， 它 涉及到的其他认知能力的丧失，如学习，推理，决策和注意。 cn.iherb.com | More serious impairment may point to [...] Dementia and Alzheimer's disease, which involves loss [...]of other cognitive abilities, such [...]as learning, reasoning, decision making and attention. iherb.com |
大量数据提示，RAGE参与阿尔茨海默病 的 发 病机制，Aβ与血脑屏障(BBB)或神经元细胞或微胶质细胞上RAGE的持续相互作用是淀粉样蛋白斑块形成和慢性神经元功能障碍的重要元素。 sharesinv.com | Substantial data suggest that RAGE is involved in the pathogenesis of Alzheimer’s disease, and that sustained Aβ interaction with RAGE at the blood-brain barrier (BBB), or in neuronal or microglial cells, is an important element of amyloid plaque formation and chronic neural dysfunction. sharesinv.com |
它还感到关切的是，保健专业人员并未接受足够的、关于如何护理痴 呆症和阿尔茨海默氏病患者 的培训，而且，公众对这些疾病的认识和理解也不 够。 daccess-ods.un.org | It is also concerned that health-care professionals do not receive sufficient training in relation to the care of persons [...] suffering from dementia [...] and Alzheimer’s and that there is a lack of awareness and understanding of the diseases among the public [...](art. 12). daccess-ods.un.org |
(a) 针对医生和保健专业人员，执行培训计划，介绍缔约国的《公约》义 务，以及痴呆症和阿尔茨海默氏病的 预 防和治疗 daccess-ods.un.org | (a) Training programmes for doctors and health-care professionals about the State [...] party’s Covenant obligations, as well as with regard to the prevention [...] and treatment of dementia and Alzheimer’s diseases daccess-ods.un.org |
AAD-2004是一种具有清除自由基和PGE2的双重药效药品，后者是引 发阿尔茨海默病 （ Al zheimer's disease）（AD）、帕金森氏症（Parkinson's [...] disease）（PD）和肌萎缩性脊髓侧索硬化症（amyotrophic [...] lateral sclerosis）（ALS）等疾病的神经损伤的关键介体。 tipschina.gov.cn | Ltdhas begun dosing in the Phase 1 clinical testing of AAD-2004AAD-2004 was developed as a dual function drug to remove free radicals and PGE2, [...] the key mediators of nerve [...] injury in Alzheimer's disease (AD), Parkinson's disease (PD), and [...]amyotrophic lateral sclerosis [...](ALS)The Phase 1 clinical trial was initiated to evaluate the safety, tolerability, and pharmacokinetics of AAD-2004 in healthy volunteers in April, 2010The first two cohorts of the clinical study have been successfully completed without serious adverse events. tipschina.gov.cn |
然而，这一大脑区域的刺激，是一个可靠的技术提高工作记忆10，增加记忆任务中的表现 在阿尔茨海默病 9 和 显 着降低线索挑起的吸烟渴求，例如35;因此它也是可以想象的，这可能是一个有用的策略来调节与慢性疼痛患者的疼痛处理相关的情感情感认知网络。 jove.com | Nevertheless, stimulation of this brain area is a reliable technique for enhancing working [...] memory 10, increasing performance on memory [...] tasks in Alzheimer disease9 and reducing cue-provoked [...]smoking craving significantly35 [...]for instance; therefore it is also conceivable that this might be a useful strategy to modulate affective-emotional cognitive networks associated with pain processing in patients with chronic pain. jove.com |
阿尔茨海默氏病国际组织的 Jan Killeen 着重指出阿尔茨海默氏病和相 关类型的痴呆与年龄歧视之间的联系。 daccess-ods.un.org | Jan Killeen of Alzheimer’s Disease International highlighted the linkages between Alzheimer’s disease and related types of dementia and age discrimination. daccess-ods.un.org |
Killeen 女士首先回顾说 9 个 65 岁以 上的人中就有 1 个人患有阿尔茨海默氏病，其 中大多数为妇女。 daccess-ods.un.org | Ms. Killeen started by recalling that 1 person in 9 over the [...] age of 65 has Alzheimer’s disease, the majority of [...]them being women. daccess-ods.un.org |
TTP488可阻断β淀粉样蛋白（即Aβ，是见 于阿尔茨海默病 患 者 细胞中的一种物质）与晚期糖基化终产物受体（即RAGE）（免疫球蛋白超级基因分子家族的成员之一）的相互作用。 sharesinv.com | TTP488 prevents the interaction of amyloid beta (Aβ), a material found in the cells of Alzheimer’s patients, and a member of the immunoglobulin supergene family of molecules known as the Receptor for Advanced Glycation Endproducts (RAGE). sharesinv.com |
老年性黄斑变性是发达国家导致失明的主要原因，其流行程度 是 阿尔茨海默 氏 病 的 两 倍，影响到全世界大约3000万人。 tipschina.gov.cn | Age-related macular degeneration is a leading cause of blindness in the [...] developed world, and is twice as [...] prevalent as Alzheimer's disease, affecting approximately [...]30 million people worldwide. tipschina.gov.cn |
在 2011年 [...] 欧洲志愿服务之际，KANIKA集团公司创办了Ithaki的的慈善组织，一个以教育塞浦路斯公众对预防和治 疗 阿尔茨海默 氏 病 为 宗 旨的非营利性组织。 kanikadevelopments.com | On the occasion of the European Year of Volunteering 2011, the KANIKA Group of Companies founded the Ithaki Charity Organization, a non-profit organization [...] with the purpose of educating the Cypriot public on matters concerning the [...] prevention and treatment of Alzheimer's disease. kanikadevelopments.com |
下列小组成员发了言：世界卫生组织(世卫组织)老龄化和生命周期司司长 John Beard、人权高专办特殊程序司经济、社会和文化权利科科长 Mara Bustelo 和阿尔茨海默氏病国际组织的 Jan Killeen。 daccess-ods.un.org | Presentations were made by the following panellists: John Beard, Director, Department of Ageing and Life [...] Course, World Health [...] Organization (WHO); Mara Bustelo, Chief, Economic, Social and Cultural Rights Section, Special Procedures Division, OHCHR; and Jan Killeen, Alzheimer’s Disease International. daccess-ods.un.org |
加龄医学研究所老年医学领域的古川胜敏准教授、荒井启行教授等基于PET淀粉样蛋白成像“BF-227”的探头，成功取得 了 阿尔茨海默 氏 病 的 老年斑的体内成像，而基于本次与信州大学的池田修一教授们的共同研究，使用相同的“BF-227”，对于患有别样甲状腺素淀粉样蛋白沉积的系统性淀粉样变的患者心肌，成功综合成像。 tohoku.ac.jp | This research group, in collaboration with a research group led by Professor Shu-ichi Ikeda at Shinshu University, has successfully visualized accumulation of transthyretin, another kind of amyloid, in the myocardium of patients with systemic amyloidosis, also using BF-227. tohoku.ac.jp |
在美国，作为《美国复苏与再投资法案》的组成部分，国家 [...] 老龄问题研究所收到了分配给国家健康研究所资金中的大约 2.75 亿美元，用于 开展对阿尔茨海默氏病、营 养、肥胖症、骨质疏松症和心血管病及保健体系利用 [...] 率、健康方面的差异等的研究工作，以及用于支助家庭照护者。 daccess-ods.un.org | In the United States, as part of the American Recovery and Reinvestment Act, the National Institute on Ageing received approximately $275 million of the funding allocated to the National Institutes [...] on Health to conduct research on [...] such issues as Alzheimer’s disease, nutrition, obesity, [...]osteoporosis and cardiovascular [...]disease, as well as health utilization, health disparities and support for family caregivers. daccess-ods.un.org |
英汉双解词典包含2273206条英汉词条，基本涵盖了全部常用单词的翻译及用法，是英语学习的有利工具。