| 单词 | 酪氨酸代谢病 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 释义 | 酪氨酸代谢病 —yrosinosisSee also:酪氨酸—tyrosine (Tyr), an amino acid 代谢—replacement • substitution • metabolism (biol.) 谢病—excuse oneself because of illness 代谢 v—metabolize v
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此外， 已知乙烯硫脲和丙烯硫脲两种二硫 代氨 基 甲 酸 酯 类 代谢 物 具 有甲状腺毒 性，较其母体化合物更值得关注。 cfs.gov.hk | Two dithiocarbamate metabolites, ethylene thiourea (ETU) and [...] propylene thiourea (PTU), are of greater concern than their [...]respective parent compounds due to their known thyroid toxicity. cfs.gov.hk |
亨特教授于1979年发现多瘤病毒中T抗原和劳斯肉 瘤 病 毒 的V-Src致癌基因都显示出一种前所未知的蛋白激酶活性，引 致 酪氨酸 磷 酸 化。 shawprize.org | In 1979, he discovered that polyomavirus middle T [...] antigen and the RSV v-Src oncoprotein both exhibit a previously unknown protein kinase activity that phosphorylates tyrosine. shawprize.org |
支链氨基酸也促进合成代谢（肌 肉增长），可用来提高运动机能。 cn.iherb.com | BCAAs are also used to potentially boost athletic performance. iherb.com |
磷酸化，或丝氨酸，苏氨酸或酪氨酸 残 基增加一个磷酸基团，是蛋白质修饰最常见的形式之一(图3A)。 labome.cn | Phosphorylation, or the addition of a phosphate group to serine, threonine, or tyrosine residues, is one of most common forms of protein modification (Fig 3A). labome.com |
KRAS 对于表皮生长因子酪氨酸激酶通路和癌细胞的生长发挥着重要的作用。 tipschina.gov.cn | KRAS serves an important [...] role in the EGFR-tyrosine kinase pathway [...]and the growth of cancer cells. tipschina.gov.cn |
A,磷酸化过程中，一个磷酸基团被结合到丝 氨 酸 ， 苏 氨酸 或 酪氨酸 残 基。 labome.cn | A, During phosphorylation, a phosphate group is [...] added to a serine, threonine, or tyrosine residue. labome.com |
骨髓间充质干细胞注射进帕金森病动物纹状体后能够存活，表达多巴胺蛋 白 酪氨酸 羟 化酶，能促进帕金 森 病 动 物 模型功能的恢复，提示帕金森病纹状体微环境可能使骨髓间充质干细胞向神经细胞分化。 chinese.eurekalert.org | Bone marrow-derived mesenchymal stem cells (BMSCs) injected [...] into the striatum can [...] survive, express tyrosine hydroxylase and promote functional recovery in Parkinson’s disease animal models, [...]indicating that BMSCs can [...]be induced to differentiate into nerve cells in the striatum of Parkinson’s disease models. chinese.eurekalert.org |
(vi) 针对于希望获得戒烟知识和实践技能、将为特殊人群提供强化戒烟支持作为其工作重心的卫生工作者 需要学习3 ——为将提供戒烟支持作为其工作一部分的医务工作者提供的所有内容，加上适用于伴心血管 疾病 或合并其它疾病的患 者、孕妇、接受精神卫生和成瘾治疗服务的患者（尤其是有严重心理障碍者）的戒烟药 物；吸烟对多种药物代谢的作 用；在依赖评估和治疗计划上允许并记录的步骤，收集和整理以保证对患者进 行标准监督和服务有效性的戒烟服务数据；使用不止一种有效的行为支持方法；对患者进行不间断的支持； 尼古丁依赖的治疗。 globalsmokefreepartnership.org | (vi) Cessation support for health staff who want to gain a knowledge base in cessation and gain the practical skills to provide intensive cessation support to specific populations as their sole focusa – all of the content for health staff providing cessation support as [...] part of their role, [...] plus cessation medications in clients with cardiovascular disease and other co-existing medical conditions, pregnant women, and users of mental health and addiction treatment services (especially for those with complex psychological disorders) effects of smoking on the metabolism of various medications; allowing and documenting [...]steps in dependence [...]assessment and treatment planning and collecting and collating data on the cessation service provided to allow the standard monitoring of clients and service effectiveness; using more than one effective behavioural support method; ongoing support for clients; and treating nicotine dependence. globalsmokefreepartnership.org |
在d-médical我们觉得通过新陈代谢治 疗糖 尿 病 是 最 准确的，可覆盖所有 与 代谢 综 合 症的 疾 病 的 治疗，也就是西方文明的疾病：糖尿病，肥胖症，高脂血症，高 尿 酸 血 症 和高血压。 d-medical.com | In d-médical fundamental believe [...] the treatment of [...] diabetes through a Metabolic Unit (UM), covering all the pathologies associated with metabolic syndrome, which come to be the diseases of Western civilization: diabetes, obesity, hyperlipidemia, hyperuricemia and hypertension. d-medical.com |
除了控制细菌细胞的基因组的化学合成( 克莱格·温特尔人工生命) ，其他方 法包括：通过在酵母中制作新陈代谢 途 径生产抗疟疾药物的前体；合成哺乳动物 基因电路揭示抗结核化合物；广泛存在的生物计算的展示；以及制作大肠杆菌以 探测和杀死人体内病原体。 daccess-ods.un.org | In addition to the chemical synthesis of a genome able to control a bacterial cell (Craig Venter’s artificial life) other important stepping [...] stones include: the [...] engineering of the metabolic pathway in yeast to produce the precursor of an anti-malarial drug; the creation of a synthetic mammalian gene circuit that revealed anti-tuberculosis compounds; a demonstration of distributed biological computation; and the engineering of an E. coli to sense and kill a human pathogen. daccess-ods.un.org |
这 4 组除害剂分别是有机磷类除害剂、氨基甲酸酯类、除虫菊素类 和拟除虫菊酯类，以及二硫代氨基甲 酸 酯 类 代谢 物。 cfs.gov.hk | This report presents the dietary exposure assessment to the residues of [...] four groups of pesticides [...] or their metabolites, namely organophosphorus pesticides (OPPs), carbamates, pyrethrins and pyrethroids, and dithiocarbamate metabolites. cfs.gov.hk |
例如维生素B1用作传送神经系统信息，缺乏这种元素会导致神经系统 疾 病 ； 维生素B2用作胺 基 酸 的 新 陈 代谢 ， 缺乏这种元素会导致精神状况变化；维生素B6则用来制造酵素及化学传递（如神经递质），缺乏这种元素就会导致神经系统疾病及抑郁；维生素B12用作合成和修补DNA，缺乏这种元素会导致神经系统异常、神经疾病及精神状况变化。 hsbc.com.hk | Vitamin B6 is necessary for the production of many enzymes and chemical [...] messengers (e.g., [...] neurotransmitters); deficiency is linked to diseases in the nerves and mental depression. [...]Vitamin B12 is needed [...]for DNA synthesis and repair; deficiency may result in neurological dysfunction, diseases in the nerves and changes in mental status. hsbc.com.hk |
最近，随着针对ADME和肿瘤学的转基因鼠模型的开发成功，Taconic已经收集了大批转基因鼠模型来专门解决肿瘤学和药 物 代谢 中 与 疾 病 和 药 品发明有关的问题。 tipschina.gov.cn | Taconic, a leading provider of life sciences solutions, announced that it has entered into a scientific development and preferred provider agreement with BioPontis Alliance LLC, a biomedical development companyBioPontis Alliance will employ Taconic's translational genetically modified models and scientific services in preclinical research efforts to accelerate the advancement of new medical discoveriesTaconic has been supplying a wide range of such models to pharmaceutical companies and academic institutions for many yearsRecently, with the development of its translational mouse models for ADME and oncology portfolios, Taconic [...] has brought together [...] collections of translational mouse models to specifically address disease and drug discovery related questions in oncology and drug metabolismTaconic links these [...]models into its compound [...]profiling platform to provide an integrated product and service offering. tipschina.gov.cn |
摘要 建立了液相色谱-串联质谱(LC-MS/MS)法用于同时测定水产品中硝基呋喃类药物 的 代谢 物 3 - 氨 基 -2-唑烷基酮(AOZ)、5-甲基吗啉-3-氨基-2-唑烷基酮(AMOZ)、氨基脲(SEM)、1-氨基-2-内酰脲(AHD)和3,5-二硝基水 杨 酸 肼 (D NSH)。 chrom-china.com | Abstract A method was developed for simultaneous qualitative [...] and quantitative [...] analysis of five metabolites of nitrofuran antibiotics, including 3-amino-2-oxazolidinone (AOZ), 5-morpholino-methyl-3-amino-2-oxazolidinone (AMOZ), semicarbazide (SEM), 1-aminohydantoin (AHD) and 3,5-dinitrosalicylic acid hydrazide (DNSH) in [...]aquatic products by [...]liquid chromatography-tandem mass spectrometry (LC-MS/MS). chrom-china.com |
蓝领工人的癌症发病率显著较高；与女性白领工作者相比，女性蓝领工 人的代谢综合征发病率较高。 daccess-ods.un.org | Blue-collar workers have significantly higher levels of [...] cancer and female bluecollar workers have a [...] higher incidence of metabolic syndrome, compared [...]with female white-collar workers. daccess-ods.un.org |
不胜枚举，例如， MilkoScan FT+ [...] 牛奶分析仪可同时测量牛奶、山羊奶、绵羊奶和水牛奶中的脂肪、蛋白质、乳糖、固形物、尿素、冰点降低值、游离脂 肪 酸 、 酪 蛋 白 、脂 肪 酸 组 成、 酮 病 和 其 他如pH值。 foss.cn | Too numerous to list here, for example, the MilkoScan FT+ milk analyser alone can simultaneously measure fat, protein, lactose, solids, [...] urea, freezing point [...] depression, free fatty acids, casein, fatty acids profile, ketosis and others [...]such as PH and H-index [...]in cow, sheep, goat and buffalo milk. foss.us |
我们确认，解剖组织进行实时PCR齿状回的特定基因，色氨酸2,3 - 双加氧酶（TDO2）和desmoplakin（DSP），和亚扪人的号角丰富的基因，MEIS相关基因1B（Mrg1b齿状回）和 TY R O 3 酪氨酸 蛋 白 激酶3（Tyro3）。 jove.com | We confirmed that the dissected tissue is dentate gyrus by conducting real-time PCR of dentate gyrus-specific genes, [...] tryptophan [...] 2,3-dioxygenase (TDO2) and desmoplakin (Dsp), and Ammon's horn enriched genes, Meis-related gene 1b (Mrg1b) and TYRO3 protein tyrosine kinase 3 (Tyro3). jove.com |
第一类是通用的 磷酸化酪氨酸，磷酸化丝氨酸，磷酸化苏氨酸抗体，将结合于任何 磷 酸 化 酪氨酸 ， 磷 酸化丝氨酸和磷酸化苏氨酸分子，与邻近的氨基酸残基无关。 labome.cn | One category is the generic phosphotyrosine, phosphoserine, and phosphothreonine antibody, which will bind to any phospho-tyrosine, phospho-serine, and phospho-threonine moeities regardless the neighboring amino acid residues. labome.com |
美白嫩膚：抑制、干擾並降解黑色素的轉化過 程 ( 酪氨酸 － 酪氨酸 酶 氧 化反應)，有明顯的美白祛斑作用，且效果溫和，功效持久。 bonjourhk.com | Whitening: suppress, interfere the dark pigment transformation and achieve whitening effect bonjourhk.com |
米哚妥林是一种针对FLT3络氨酸激活酶的定向小分子抑制剂，目前正处于第三阶段临床开发中，给新确诊的FLT3突变急性髓细胞白 血 病 患 者 服用米哚妥林或服用安慰剂并结合化学疗法（NCT00651261）进行对比试验。 tipschina.gov.cn | Midostaurin, [...] a targeted small molecule inhibitor of FLT3 tyrosine kinase, is currently in Phase III clinical development for newly diagnosed patients with FLT3 mutated AML who are receiving [...]midostaurin or a [...]placebo in combination with chemotherapy (NCT00651261). tipschina.gov.cn |
选择低脂肪的肉类，每周吃一次以上的无肉家庭晚餐，使用低脂或脱脂牛奶、低 脂 酸 奶 和 奶 酪 ， 用 自制点 心 代 替 从 商店里买来的饼干和蛋糕，这些都将使您的饮食更加有利于心脏的健康。 shanghai.ufh.com.cn | Try having one or more meat-free family [...] meals per week, using low-fat or [...] fat-free milk, low-fat yogurt and cheese. As well, making the switch [...]from store-bought cookies [...]and cakes to homemade will make your diet more heart-healthy. beijing.ufh.com.cn |
以相对峰面积作为原始数据,通过Matlab7.1软件平台,用偏最小二乘判别分析(PLS-DA)得分图进行关联研究,结果表明: 与对照组相比,培养基游离氨基酸代谢 消 耗谱能够区分两种不同机制的抗癌药物,为抗癌药物筛选过程中的药物作用机制预归类提供了一种新的技术方法。 chrom-china.com | Relation analysis performed by partial least squares-discriminant analysis (PLS-DA) indicated [...] that in comparison with the control [...] group, the media amino-acid consumption profiling [...]can distinguish the two anticancer [...]drugs with different mechanisms, which provides a new perspective for the pre-classification of drug action mechanisms during the screening of new anticancer drugs. chrom-china.com |
根据一份单独的分销协议，Taconic还将冷藏保存、繁育及分销Caliper的产生荧光转基因动物（LPTA(R) ）模型，这一套独特的模型利用生物发光分析技术改良肿瘤、炎症 、 代谢 及 内 分泌 疾 病 研 究和药物毒性研究。 tipschina.gov.cn | Pursuant to a separate distribution agreement, Taconic will also cryopreserved, breed and distribute Caliper's Light Producing Transgenic Animals (LPTA(R) models), a unique line of models that use [...] bioluminescent technology to improve oncology, [...] inflammation, metabolic and endocrine disease research and [...]drug toxicology studies. tipschina.gov.cn |
这意味着SO2代谢衍生 物对中枢神经系统具有损伤作用，从而提示大气SO2污染可能与一些中枢神经系统 疾 病 的 发 生以及衰老有关［动物学报 49(1)：73～79，2003］。 actazool.org | The results imply that SO2 derivatives are damaging to the CNS and that SO2 pollution in the atmosphere is related to the CNS diseases ［ Acta Zoologica Sinica [...] 49(1):73-79, 2003］. actazool.org |
应食品卫生法典委员会的要求，粮农组织/世卫组织 乳 酸 过 氧 化物酶系统原料乳保 鲜的作用和潜在危险的技术会议（2005 年 11 月 28 日－12 月 2 日，意大利罗马）48 ，已 经召开，第三十五次 JECFA 会议的资料和安全评估都显示，按照导则使用 LPS，其成分 或代谢物都不会产生安全问题。 codexalimentarius.org | A joint FAO/WHO technical meeting on benefits and potential risks of the lactoperoxidase system of raw milk [...] preservation (Rome, Italy, 28 November - 2 [...] December 2005)48 had been convened upon request of the Committee on Food Hygiene and data as well as the safety evaluation by the 35th meeting of JECFA had indicated that there were no safety concerns relating to the components or metabolites of the LPS when used in accordance with the Guidelines. codexalimentarius.org |
一些疾病在不同年龄事都可能表现出初期症状，应尽早检测出这些疾 病并且给予专业治疗，从而使儿童获益，例如应尽早检 测 代谢 疾 病、 听 力损失、髋关节发育不良、隐睾症、斜视、视力问题、青春期发育 问题、肥胖、自闭症、注意力缺陷及多动症，对于有生理残疾或心理 残疾的儿童进行检测及跟踪治疗，对于患有慢性疾病儿童进行跟踪治 疗。 daccess-ods.un.org | Detection of health problems (with ab initio presentation at the different ages) which may benefit from early detection coordinated with specialist care by means of activities designed to ensure early detection of metabolopathies, hypoacusis, displasia of the hip joint, cryptorchidism, strabism, vision problems, puberal development problems, obesity, autism and attention deficiency and hyperactivity disorders, and also identification and monitoring of children with physical and psychological disabilities and chronic diseases daccess-ods.un.org |
结论PCOS [...] IR可能为胰岛素受体后信号转导通路中，其上游信号分子 IR S - 1 酪氨酸 磷 酸 化的改变造成激活信号减弱，使PI-3K活性降低，影响胰岛素信号通路中信号分子的生物学作用，导致IR形成。 zhhyx.com.cn | Conclusion In consequence of the weaker signal caused [...] by the change of upper stream signal [...] molecule IRS-1 tyrosine phosphorylation, [...]PI-3 kinase activity decreased, it affects [...]the insulin signal pathway leading to insulin resistance in PCOS. zhhyx.com.cn |
异位表达这两个蛋白，对Myc标签TH1进行免疫沉淀，使用通用 的 酪氨酸 磷 酸 化抗体检测在c-Src表达有或无的情况下TH1的磷酸化 [22] 。 labome.cn | The two proteins are ectopically expressed, an immunopercipitation against Myc-tagged TH1 is performed, and a general phosphotyrosine antibody is used to assess TH1 phosphorylation in the absence or presence of c-Src expression [22] . labome.com |
英汉双解词典包含2273206条英汉词条，基本涵盖了全部常用单词的翻译及用法，是英语学习的有利工具。