| 单词 | 细胞色素 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 释义 | 细胞色素 —cytochromeSee also:细胞 n—cytoplasm n 细胞—cell (biology) 色素 n—colorAE n • colours pl • coloring n 色素 pl—pigments pl • colourings pl 色素—pigment
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通过消除肝脏细胞色素P450活 性，HRN（TM）小鼠能让研究者们使用少得多的宝贵的先导化合物，更清楚地证明体内的药效。 tipschina.gov.cn | By eliminating hepatic cytochrome P450 activity, [...] the Taconic HRN(TM) mouse enables researchers to demonstrate in vivo drug [...]efficacy more clearly, using much smaller amounts of valuable lead compounds. tipschina.gov.cn |
Taconic客户关系部高级副总裁Kevin Leak说：“细胞色素P450代 谢是药物生物利用的一个重要混杂因素，对其进行研究是药物发现取得进展的关键。 tipschina.gov.cn | Cytochrome P450 metabolism is a major confounding factor in the bioavailability [...] of drugs, making its study vital to the [...]advancement of drug discovery," said Taconic Senior Vice President, Client Relations, Kevin Leak. tipschina.gov.cn |
一种新型多倍人源化鼠系中人体孕烷X受体 及 细胞色素 P 4 50 3A4介导的药物间相互作用的定量预测。 tipschina.gov.cn | Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line. tipschina.gov.cn |
新细胞色素P450 Cyp2c基因簇剔除和CYP2C9人源化小鼠系的生成和特性。 tipschina.gov.cn | Generation and [...] Characterization of Novel Cytochrome P450 Cyp2c [...]Gene Cluster Knockout and CYP2C9 Humanized Mouse Lines. tipschina.gov.cn |
这种POR（细胞色素P450氧化还原酶）条件性靶向性敲除不会在肝脏表 达 细胞色素 P 4 5 0还原酶，这样，对药物体内分布起重要作用的肝 脏 细胞色素 P 4 5 0变 得无效。 tipschina.gov.cn | This conditional, targeted knockout of Por does not express cytochrome P450 reductase in the liver, and thus liver cytochrome P450s, known to play a major role in drug disposition, are inactive. tipschina.gov.cn |
人和动物的细胞色素P450蛋白这一大型且种类繁多的家族都可通过去除P450还原酶基因使其无效。 tipschina.gov.cn | The large, [...] diverse family of cytochrome P450 proteins [...]in humans and animals all can be rendered inactive by deleting the gene for P450 reductase. tipschina.gov.cn |
一份题为《一种新型多倍人源化小鼠系模型中人体孕烷X受体 及 细胞色素 P 4 50 3A4介导的药物交互作用的定量预测》的文件表明该小鼠模型可用于根据PXR配体诱导CYP3A4在人体肝脏表达的效力对其进行排序。 tipschina.gov.cn | The paper, entitled "Quantitative prediction of human pregnane [...] X receptor and cytochrome P450 3A4 mediated [...]drug-drug interaction in a novel multiple [...]humanized mouse line," demonstrates that the mice can be used to rank PXR ligands according to their potency to induce CYP3A4 expression in the human liver. tipschina.gov.cn |
进一步的实验表明，Roquefortine C [...] 是一种潜在的神经毒性化合物，可激活解毒酶 P-糖蛋白 (P-gp)，并抑制细胞色素 P450-3A。 scbt.com | Further experiments report that Roquefortine C is potentially a neurotoxic [...] compound that activates and inhibits detoxification enzymes [...] P-glycoprotein (P-gp) and cytochrome P450-3A, respectively. scbt.com |
由于这个原因，研究者使用MNG-3考察了从莱茵衣藻里提取 的 细胞色素 b6 f 复合物的结晶。 labome.cn | For this reason the researchers have examined the crystallization of the cytochrome b6 f complex from Chlamydomonas reinhardtii using MNG-3. labome.com |
此外,基于线粒体细胞色素b 基因 全序列,构建31 个兔类个体的系统发育关系,结果显示,草兔与雪兔(L. [...] timidus),云南兔(L. comus) 与高原兔(L.oiostolus),东北兔(L. mandschuricus)与塔里木兔(L. [...]yarkandensis) 有较近的亲缘关系,而在草兔内部,中国的草兔与南非草兔亲缘关系较远,采自江苏盐城的草兔与来自山东、陕西、四川的草兔聚为一支,具有明显较近的亲缘关系。 mammal.cn | The results strongly supported the monophyly of Lagomorpha,and [...] cape hare and brown hare (L. europaeus)were [...]indicated as sister taxa,having a sister [...]relationship with rabbit (Oryctolagus cuniculus). Further phylogenetic analyses of 31 hare samples,based on complete Cyt b sequences,resolved the close phylogenetic relationships between cape hare and mountain hare (L. timidus),Yunnan hare (L. comus)and woolly hare (L. oiostolus),Manchurian hare (L. mandschuricus)and Yarkand hare (L. yarkandensis),respectively. english.mammal.cn |
家蚕与果蝇的ND2基因序列同源性约69.7%，COⅠ基因的同源性约83.8%，COⅡ基因5′端的同源性约80%，这表 明 细胞色素 氧 化 酶基因在物种间比烟酰胺腺嘌呤二核苷酸脱氢酶基因保守。 actazool.org | The homology of ND2 gene sequence between Bombyx mori and Drosophila melanogaster is about 69.7%, while the homology of COⅠ and 5′end of COⅡ gene sequences between B.mori and D. melanogaster is about 83.8% and 80% respectively. actazool.org |
基因泰克团队通过不同人细胞色素P45 0代谢且反映低、中、高清除率的化合物在HRN（TM）小鼠和野型对照小鼠体内的药代动力学变化的鉴别，对该模型进行了评估。 tipschina.gov.cn | The Genentech team evaluated the model by characterizing changes in pharmacokinetics of test articles in the HRN(TM) mouse and in wild type controls, using compounds metabolized by different human cytochrome P450s and those reflecting low, medium and high clearance. tipschina.gov.cn |
结果显示:1)不同繁殖组哺乳高峰期的摄食量、泌乳能量支出(MEO)、胎仔数和胎仔重差异不显著,静止代谢率(RMR)、非颤抖性产热(NST)、褐色脂肪组织(BAT)线粒 体 细胞色素c 氧化 酶(COX)活性、血清甲状腺激素(T3 、T4 )和催乳素水平也无明显变化;2)摄食量与MEO、胎仔重和RMR 呈显著正相关。 mammal.cn | The present study showed that 1)asymptotic food intake,milk energy output (MEO),litter size and mass,resting metabolic rate (RMR),nonshivering thermogenesis (NST),mitochondria cytochrome c oxydase (COX) activity of brown adipose tissue (BAT),serum T3 ,T4 and prolactin levels did not differ between the four bouts of lactation; 2)the asymptotic food intake was significantly correlated with MEO,litter mass and RMR. english.mammal.cn |
从4个地理种群的51个样品中成功地扩增出了535 bp的线粒体DNA细胞色素b（mt DNA Cyt b）片段，在所有可比较的535 bp的序列中，发现15个变异位点，没有插入／缺失，且很大程度上倾向于转换(Transition)或颠换(Transversion)，Ti/Tv=3.4﹕1，并且变异位点多发生在密码子的第三位点，而密码子的第二位点没有变异位点。 actazool.org | Using polymerase chain reaction(PCR) and direct sequencing methods to analyze the genetic structure and molecular phylogeography of the Tibetian snowcock Tetraogallus Tibetiananus przewalskii in China, a total 535 bp nucleotides of the mitochondrial DNA (mtDNA) Cyt b genes were sequenced in 51 Tibetian snowcock collected from four geographic populations in the north mountains of Qinghai-Tibetian Plataeu. actazool.org |
一项由Kusus等人的研究表明，不宜使用充 当 细胞色素 P 4 50 3A路径底物或P-糖蛋白底物的药物，以免发生由3-羟基-3-甲基-戊二酰基-辅酶A还远酶抑制剂引起的横纹肌溶解。 aging-management.com | A study by Kusus et al suggests that drugs that act as [...] substrates for the cytochrome P450 3A4 pathway [...]and/or P-glycoprotein substrates should [...]be avoided to reduce rhabdomyolysis caused by 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors. aging-management.com |
然而，羽毛色素细胞的黑色素沉 积与抗氧化能力和免疫系统有很强的联系，而抗氧化能力和免疫系统在提高有机体适合度方面具有重要的功能。 actazool.org | However, melanin deposition in feather melanocytes has strong links with the capacity of the antioxidant and immune systems, two crucial fitness-enhancing organismic functions. actazool.org |
MSS也可用于对 多种切片进行分析，包括基底细胞及鳞状 细胞癌、恶性黑色素瘤、B细胞淋巴癌、 极性粒细胞白血病及转移性乳腺癌。 polysciences.com | MSS also [...] differentiates various cytologic processes, including basal cell & squamous cell carcinomas, malignant melanoma, B-cell lymphoma, [...]acute myelomonocytic [...]leukemia and metastatic breast cancer. polysciences.com |
2、位于眼内部位肿瘤，多为视网膜母 细胞 瘤 、 脉络膜 黑 色素 瘤 等 ，主要表现为有眼压升高、眼痛、头痛，视力减退等。 asiancancer.com | 2、When the tumors are located inside the eyes, they usually are retinoblastoma and choroidal melanoma, which mainly presented with ocular high pressure, eye pain, headache and poor eye sight. asiancancer.com |
在医药领域，以色列最近开发了一种手机成像 应用，利用特殊镜头寻找疟原虫消化分解血 红 细胞产 生的疟色素确诊疟疾病例。 daccess-ods.un.org | In the medical field, Israel had recently developed a mobile-phone-based imaging application which enabled malaria to be diagnosed in the [...] field by using a special lens to look for the pigment that the [...] malaria parasite generated when it digested red blood cells. daccess-ods.un.org |
此次，研究小组用老鼠培养出的黑 色素细胞 ， 查 明了在这些树状突起形成过程中，被称为“Varp”的Rab21活化因子与其相关。 tohoku.ac.jp | In this study, the research group has revealed that the activation of Rab21 by Varp is required for dendrite formation, by using cultured mouse melanocytes. tohoku.ac.jp |
作为我们的皮肤或发色的基本组成的黑色素是由被称为“ 黑 色素细胞 ” 的 特殊 细 胞 由 黑 色 素 合成酶合成的，储藏在称为“黑色素小体”的细胞内囊（卵泡）中。 tohoku.ac.jp | Melanin pigments, sources of our skin color and hair color, are synthesized by melanogenic enzymes in melanocytes, and are stored in specialized organelles called melanosomes. tohoku.ac.jp |
在过去五年中，遗传材料的合成从有关病 毒、细菌、哺乳动物细胞器官到利用真 核 细胞 部 分 合成 染 色 体。 daccess-ods.un.org | Over the past five years, synthesis of genetic material has moved [...] from viral settings, through bacterial settings, and [...] mammalian organelles, to partial synthesis of a chromosome from a eukaryote. daccess-ods.un.org |
娇韵诗实验室发现海百合萃取精华能够控制s树突（也就是阻断 黑 素细胞 向 表 皮分泌出 黑 色 素 的 “通道”）的延伸。 clarinsusa.com | This is why Clarins Laboratories, who discovered that Sea Lily extract was able to control extension of dendrites - the "arms" of melanocytes which deliver melanin pigments to the epidermis - only use plants from controlled cultivation. clarinsusa.com |
除非你不打算运行四个以上的荧光染料并且所有的 染 色 都 是 在 细胞 表 面 ，最好是跟有经验的使用者紧密合作，能避免所有自学者犯的常见错误。 labome.cn | Unless you never plan to run more than four fluorochromes [...] and all your staining is of the cell surface, it [...]is best to work closely with an experienced [...]user in order to bypass all of the common mistakes made by the self-taught. labome.com |
barbel附属物虽然没有人类的模拟，它包含的细胞类型是高度保守的，从而有可能研究皮肤，腺体， 黑 色素细胞 ， 循 环系统血管和神经在光学明确和解剖学简单的圆柱形结构。 jove.com | Although the barbel appendage has no human analog, the cell types it contains are [...] highly conserved, making it possible to study [...] skin, glands, melanocytes, circulatory vessels [...]and nerves in an optically clear [...]and anatomically simple cylindrical structure. jove.com |
但是，本周发表在《科学快讯》中的2项新的研究证明，大约71%的人类 黑 色素 瘤 在 TERT基因中具有2种 体 细胞 突 变 中的1种，该基因编码端粒酶的1个亚基；端粒酶是覆盖在染色体端部的酶。 chinese.eurekalert.org | Two new studies in this week’s issue of Science Express, however, [...] demonstrate that about 71 [...] percent of human melanomas harbor one of two somatic mutations in the TERT [...]gene, which encodes a [...]subunit of telomerase, the enzyme that caps the ends of chromosomes. chinese.eurekalert.org |
通过将番泻树、橄榄树、悬铃树和豌豆与猴面包树结合，娇韵诗实验室创造出了独一无二的防晒护理产品——植物性阳光防护 元 素 2 （ Ph yto Sunactyl 2），能够保护皮肤细胞及其 遗传免受太阳的侵袭。 clarinsusa.com | By combining senna, olive, plane tree and pea with baobab, Clarins Laboratories created Phyto-Sunactyl 2, the exclusive [...] complex present in Clarins sun products [...] which protects skin cells and their genetic inheritance against the sun’s aggressions. clarinsusa.com |
此外，人们发现，在哺乳动物中调节 黑 色 素 沉积的激素，即α - 黑 素细胞 刺 激 素，在鸟类上皮组织 的 色 素 沉 积中也具有同样的功能。 actazool.org | Also, the hormone regulating melanin deposition in mammals, α-melanocyte-stimulating hormone, has been found to work in birds as well and with the same function with respect to pigmentation of tegumentary structures. actazool.org |
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