| 单词 | 激酶 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 释义 | 激酶 noun —kinase nSee also:激—stimulate • arouse • fierce • incite 酶 n—enzyme n • enzymes pl • diastase n • malt n 酶—ferment • researching
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位于尿激酶型纤溶酶原激活剂 基因第6外显子rs2227564位点的C/T错义多态性被认为是可能与阿尔茨海默病发病相关的热议位点。 chinese.eurekalert.org | A missense C/T polymorphism in exon 6 (the NCBI rsID is rs2227564) of the urokinase-type plasminogen activator gene has been identified as a possible hot spot for Alzheimer’s disease risk. chinese.eurekalert.org |
此外，与蛋白质敲除实验相结合，这种方法也可用来分析一个特定 的 激酶 或 磷酸酶是否影响靶蛋白的修饰状态。 labome.cn | Furthermore, in conjunction with a protein knock-down step, [...] this method can also be used to implicate a [...] specific kinase or phosphotase in [...]the modification status of the target protein. labome.com |
KRAS 对于表皮生长因子酪氨酸激酶通路和癌细胞的生长发挥着重要的作用。 tipschina.gov.cn | KRAS serves an important role in the [...] EGFR-tyrosine kinase pathway and the [...]growth of cancer cells. tipschina.gov.cn |
根据双方达成的协议，COARE将负责对双肾上腺皮质激素 样 激酶 1 （ DC LK1）在癌症干细胞增殖分化过程中的作用开展开创性研究，包括相关的筛查试剂和技术。 tipschina.gov.cn | Under terms of this agreement, COARE contributes its pioneering research on the role of Doublecortin-like Kinase 1 (DCLK1) in proliferation and differentiation of CSC including relevant screening reagents and know-how. tipschina.gov.cn |
以前的研究提示亚胺环己酮可能是通过抑制蛋 白 激酶 M O S 的合成来发挥孤雌激活的作用的。 actazool.org | Previous studies suggest that CHX activation occurs through the inhibition of MOS (a Ser/Thr protein kinase) synthesis. actazool.org |
过氧物酶体增生物激活受体激动剂（例如 GW1516）和磷酸腺苷激活蛋白 激酶（AMPK）中枢激动剂（例如 AICAR）被重新划定为改变细胞代谢的 物质。 unesdoc.unesco.org | Peroxisome Proliferator Activated Receptor δ (PPARδ) agonists (e.g. GW 1516) and PPARδ-AMP-activated protein kinase (AMPK) axis agonists (e.g. AICAR) have been re-categorized as substances that modify cellular metabolism. unesdoc.unesco.org |
在反应缓冲液中，温育纯化的靶蛋白 ， 激酶 ， 和32P-gamma-ATP。 labome.cn | Purified [...] target protein, kinase, and 32P-gamma-ATP [...]are incubated in a reaction buffer. labome.com |
根据目标抗体是否分泌并在高尔基体内滞留 ， 激酶 或 磷 酸化蛋白是否需要磷酸酶抑制剂，核蛋白是否需要磷脂双分子层部分溶解和DNA松弛，细胞透化需要选择不同的方式。 labome.cn | There are [...] different choices for cell permeabilization depending on whether the antibody target is to be secreted and therefore sequestered in the Golgi, a kinase or phosphoprotein [...]that requires [...]aggressive inhibition of phosphatases, or a nuclear protein that requires partial dissolution of two membranes and relaxation of the DNA. labome.com |
这是一种口服的ALK抑制剂，设计用途是检测晚期非小细胞肺癌患者间变型淋巴 瘤 激酶 ( A L K) 基因的重组。 china.labmedica.com | It is designed to detect rearrangements of the [...] anaplastic lymphoma kinase (ALK) gene in [...]advanced non-small-cell lung cancer (NSCLC) patients. labmedica.com |
放射测量激酶反应 使用32P-gamma-ATP，可用于检测体外磷酸化状态 [8] 。 labome.cn | Radiometric kinase reactions using [...] 32P-gamma-ATP can be used to assay phosphorylation status in vitro [8] . labome.com |
SBI提供基于HIV和FIV的慢病毒载体，其载体有很多启动子，取决于要转导的细胞类型：CMV（巨细胞病毒）用于HeLa及其他多种细胞；HEK293和HT1080转导；MSCV（小鼠干细胞病毒）用于造血细胞和干细胞转导；UbC（泛素C）用于转导大部分类型的细胞；PGK（磷酸甘油 酸 激酶 ） 用于转导大部分类型的细胞；EF1（延伸因子1α）用于转导大部分类型的细胞。 labome.cn | SBI offers lentiviral vectors that are HIV- and FIV-based and have many promoters, depending on the cell type being transudced: CMV (Cytomegalovirus) for HeLa and many other cell types and for HEK293 and HT1080 transduction; MSCV (Murine Stem Cell Virus), for hematopoietic and stem cell transduction; UbC (Ubiquitin C), for transducing most cell types; PGK (Phosphoglycerate Kinase), for transducing most cell types; and EF1 (Elongation Factor 1α), for transducing most cell typesIn addition to the transfer vectors listed below, they offer inducible and dual promoter backbones. labome.com |
今天宣布，美国食品药品监督管理局（FDA）已批准该公司用于治疗 II型糖尿病的同类首创激酶活化 剂MLR-1023的新药临床试验申请（IND）。 businesswirechina.com | (BUSINESS WIRE)--Melior Discovery, Inc. today announced that the United States Food and Drug Administration (FDA) has approved its Investigational New Drug (IND) application [...] for the clinical development of its novel [...] first-in-class kinase activator, MLR-1023, [...]for the treatment of Type II diabetes. businesswirechina.com |
亨特教授于1979年发现多瘤病毒中T抗原和劳斯肉瘤病毒的V-Src致癌基因都显示出一种前所未知的蛋 白 激酶 活 性 ，引致酪氨酸磷酸化。 shawprize.org | In 1979, he discovered that polyomavirus middle T [...] antigen and the RSV v-Src oncoprotein both exhibit a previously [...] unknown protein kinase activity that [...]phosphorylates tyrosine. shawprize.org |
几种体内的和体外的方法，被用于检测蛋白质的磷酸化状态，检测一个特定氨基酸的磷酸化，以及确定一个特定 的 激酶 （ 或磷酸酶）是否作用于目标蛋白质。 labome.cn | Several in vivo and in vitro methods are used to assess protein phosphorylation status, to assess [...] phosphorylation of a specific amino acid, and to ascertain whether [...] a specific kinase (or phosphatase) modifies [...]a protein in question. labome.com |
如果是激酶或磷酸蛋白，其磷酸酶需要迅速失活，因此PFA通常在37℃下使用。 labome.cn | For kinases and phosphoproteins, [...] where inactivation of phosphatases needs to be rapid, the PFA is often used at 37oC. labome.com |
我们确认，解剖组织进行实时PCR齿状回的特定基因，色氨酸2,3 - [...] 双加氧酶（TDO2）和desmoplakin（DSP），和亚扪人的号角丰富的基因，MEIS相关基因1B（Mrg1b齿状回）和TYRO3酪氨酸蛋 白 激酶 3 （ Ty ro3）。 jove.com | We confirmed that the dissected tissue is dentate gyrus by conducting real-time PCR of dentate gyrus-specific genes, tryptophan 2,3-dioxygenase (TDO2) and [...] desmoplakin (Dsp), and Ammon's horn enriched genes, Meis-related gene 1b (Mrg1b) and TYRO3 [...] protein tyrosine kinase 3 (Tyro3). jove.com |
2010年，Oncodesign在它的发现活动中加入了医药化学技术：Nanocyclix（R），致力于高效力、高选择性的新 型 激酶 抑 制 剂的合成。 tipschina.gov.cn | In 2010, Oncodesign has incorporated a medicinal chemistry technology into its [...] discovery activity: Nanocyclix（R）, which is dedicated to the synthesis of highly potent and [...] selective novel kinase inhibitors. tipschina.gov.cn |
神经管畸形与细胞凋亡有关，目前已发现存在着多条丝裂原活化蛋 白 激酶 信 号转导通路可激活细胞凋亡通路。 chinese.eurekalert.org | Neural tube defects are related to cell apoptosis. At present, there have been mitogen activated protein kinase singal transduction pathways that can activate cell apoptosis pathway. chinese.eurekalert.org |
对于激酶和磷 酸化蛋白来说，相关技术来自斯坦福大学的Gary [...] Nolan 实验室 [6] [7] 。 labome.cn | For kinases and phosphoproteins, [...] the technology comes from the laboratory of Gary Nolan at Stanford [6] [7] . labome.com |
权衡这两种假说，目前的证据倾向于支持阳性信号假说，而且最近的研究暗示，该种阳性信号的产生发生在颗粒细胞中LH诱导的cAMP水平上升和 M A P K 激酶激 活 之 后。 actazool.org | Moreover, recent studies suggest that this signal is probably generated downstream of LH induced elevation of granulosa cell cAMP and the activation of mitogen activated kinases (MAPK) in the granulosa cells. actazool.org |
代谢调节剂: 过氧化物酶体增殖剂应答性受体 δ(PPARδ)激动剂 (例 如：GW 1516), PPARδ-AMP 腺苷酸-活化蛋白激酶(AMPK) 轴激动 剂(例如：AICAR). unesdoc.unesco.org | Metabolic modulators: Peroxisome Proliferator Activated Receptor δ (PPARδ) agonists (e.g. GW 1516), PPARδ-AMP-activated protein kinase (AMPK) axis agonists (e.g. AICAR). unesdoc.unesco.org |
在影片中與德-異-SJ-不只是武裝力量 － － － 視圖與更像是 inownership，但還他們安娜-茲與寶勒成為的黏著 斑 激酶 中 央，認識的十多個 － － － － 登，桌上的頭角 － － － 發展方案對滑裡 － － － 做 EV 補方案階。 journal.g-sochi.ru | In the movie HEAD on DESK with der-INH-SJ-not only to CFE view with more like inownership, but also their Ana-Liz, with Po-Le-becoming of FAK-Tov, awareness of ten more den, RAS development scenarios for slid the RI do EV BU sche-th. journal.g-sochi.ru |
这也是检测特定激酶作用的金标准。 labome.cn | This is also the gold standard for [...] assessing the role of specific kinases. labome.com |
这种激酶是开发创新型特效抗癌疗法的一个有希望和易控制的目标。 tipschina.gov.cn | This kinase is a promising [...] and tractable target for the discovery of novel specific anti-cancer therapies. tipschina.gov.cn |
在欧洲市场上市的一种间变型淋巴瘤 激酶 ( A L K) 基因检验可作为晚期非小细胞肺癌(NSCLC)患者的结合诊断检验。 china.labmedica.com | An anaplastic lymphoma kinase (ALK) gene test [...] was introduced in EU market as a companion diagnostic test in advanced non-small-cell lung cancer (NSCLC) patients. labmedica.com |
吡哌酸 那屈肝素；其鹽類 尿激酶 普立地諾；其鹽類 泛硫乙胺；其鹽類 舍莫瑞林；其鹽類 普羅瑞林；其鹽類 美沙拉秦；其鹽類 苯溴馬隆 氨甲環酸 萘呋胺；其鹽類 萘啶酸 解磷定；其鹽類 鏈激酶”。 legco.gov.hk | Streptokinase Tranexamic acid Trifluridine; its salts Trimethoprim Tromantadine; its salts Urokinase”. legco.gov.hk |
在早期开发领域，Progenics [...] 公司正在评估艰难梭菌毒素的新型抗体和单药复合 PI3 激酶抑制 剂，有望用于攻克部分侵犯性最强的癌症，同时研究中的还有丙型肝炎感染的新型侵入抑制剂。 mdsol.com | In early development, Progenics is evaluating novel antibodies to toxins produced by the [...] bacteria C. difficile, as well as single-agent [...] multiplex PI3-Kinase inhibitors as [...]a potential strategy to combat some of the [...]most aggressive forms of cancer, and is also seeking to identify novel entry-inhibitors of HCV infection. mdsol.com |
目的 研究多囊卵巢综合征（PCOS）患者脂肪组织胰岛素受体底物-1（IRS-1）介导的磷脂酰肌 醇 - 3 激酶 （ PI -3K）活性的改变，探讨PCOS产生胰岛素抵抗(IR)分子的机理。 zhhyx.com.cn | Abstract】Objective To investigate the insulin receptor [...] substance-1 (IRS-1)-mediated [...] phosphatidylinositol-3 (PI-3) kinase activity in adipose [...]tissue of polycystic ovary syndrome [...](PCOS) patients, and to explore molecular mechanisms of insulin resistance of PCOS. zhhyx.com.cn |
同时制定并实施了一系列行业标准：《对受艾滋病毒感染人群保守治疗标 准》(2001 年)、《针对受艾滋病毒感染人群的抗转 录 酶 病 毒药物治疗和防止艾滋 病毒的母婴传播和职业感染的标准》(2001 年和 2003 年)、《艾滋病毒感染的流 行病学监测标准》(2002 年)、《艾滋病、肝炎和其他病毒感染实验室与诊断机构 组织实施抗击流行病计划操作指南》(2004 年)、《艾滋病毒母婴传播》单元 (2004 年)、《艾滋病毒检测咨询前后的方法指导》(2005 年)。 daccess-ods.un.org | Sector standards have been developed and implemented: “Palliative treatment of the persons infected with HIV and AIDS” (2001), “Treatment with antiretroviral medicine specific for persons infected with HIV and AIDS and the prophylaxis of transmission of the mother-child HIV infection, professional exposure” (2001 and 2003), “Epidemiologic supervision of the HIV/AIDS infection” (2002); Instructions on the organisation of the antiepidemiologic programme in the AIDS, hepatitis and other viral infections laboratories and diagnosis sections” (2004), The module “HIV and AIDS infections with mother-child transmission” (2004), Methodological Guide “Before and after HIV test counselling” (2005). daccess-ods.un.org |
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