no obj.
1- become in need of rest or sleep; grow weary感到疲劳（或累）：
soon the ascent grew steeper and he began to tire.
不久坡度越来越陡, 他开始觉得累了。
1.1
- with obj. cause to feel in need of rest or sleep; weary使感到疲劳（或累）：
the journey had tired her
旅途使她劳累
the training tired us out.
训练把我们累坏了。
1.2
tire of
lose interest in; become bored with厌倦, 厌烦：she will stay with him until he tires of her.
她将会和他呆在一起, 直到他厌烦她。
1.3
- with obj. exhaust the patience or interest of; bore使厌倦, 使厌烦：
it tired her that Eddie felt important because he was involved behind the scenes.
埃迪因为参与幕后事宜就自以为了不起, 这让她心烦。
词源
Old English tēorian 'fail， come to an end'， also 'become physically exhausted'， of unknown origin.