A loss in the primary elections will mean the end of the road for his campaign.在初选中败北将意味着他竞选道路的终结。

It will be the end of the line for me unless there are some changes around here.除非还有一些变数，不然的话这就是我的尽头。

They reached the end of the road as a couple [=their relationship was over] a long time ago.很久以前他们的婚姻就走到了尽头。