We may not get another chance, so we need to make the best of this opportunity.我们也许不会再有机会了，因此我们要充分把握这次机会。

Life is not very good right now—but let's try to make the best of it.眼下日子不太好过，但我们还是尽力让逆境为我们所用吧。

We're trying to make the best (out) of a bad situation. = (Brit) We're trying to make the best of a bad job.我们正设法在不利情况下尽量妥善地处理问题。