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Cost can make a difference in deciding on a college.费用可能影响到选择上哪所大学。
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“When would you like to leave?” “It makes no difference (to me).” [=it doesn't matter to me; I don't care]“你想什么时候离开？”“（我）无所谓。”
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The weather didn't make any difference in our plans. [=didn't change our plans]天气没有影响我们的计划。
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It would make a lot of difference if you came.如果你来，情况就会有很大不同。
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Your help made a big difference.你的帮助起了很大作用。
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It makes very little difference. [=it matters very little]这无关紧要。
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The size of the engine can make all the difference. [=can be very important; can matter most]引擎的大小关系重大。
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It may not matter to you, but it makes all the difference in the world to me. = It makes a world of difference to me. [=it matters very much to me]这对你而言可能不算什么，但对我来说却至关重要。