Whoever benefits from the new government programs, the American taxpayer is bound to lose out in the end.无论是谁从政府的新计划中获益，最终吃亏的肯定都是美国的纳税人。

If you don't invest with us, you'll be losing out on a great opportunity! [=you'll be missing/wasting a great opportunity]如果你不给我们投资，你将错失良机。

She lost out to a better-known actress for the lead role. [=she did not get the lead role because a better-known actress got it]她没演成女主角，输给了一个知名度更高的女演员。