She led off [=started, kicked off] the presentation with a brief overview of the project.她以对这个工程的简要概述开始了自己的发言。

She led off [=began] with a brief overview of the project.她以对这个工程的简要概述开始了自己的发言。

He led off with a walk. [=he was the first batter in his team's half of the inning and he was walked]他是第一个上场的击球手，并获得保送上垒。

He led off the inning with a home run.那局比赛他是第一个上场的击球手，并打出了本垒打。