alienate

He feels very alienated from his parents.他感觉跟父母关系很疏远。

alienated young people [=young people who do not feel that they have a part in society]与社会格格不入的年轻人

Her position on this issue has caused the alienation of many former supporters.她在此问题上的立场使许多曾经的支持者离她而去。

His alienation from his parents stems from his drug problems.他与父母关系疏远是因为他吸毒。

She has struggled with feelings of loneliness and alienation for much of her adult life.成年以后的很多时候，她一直在寂寞和孤独中苦苦挣扎。