disadvantage

This program has the disadvantage [=shortcoming] of being more expensive than the others.这一方案的缺点是比其他方案费钱。

She had the disadvantage of growing up in a poor community.她的劣势在于出身贫寒。

He felt that his lack of formal education put/placed him at a disadvantage [=made it harder for him to succeed] in the business world.他感到缺乏正规教育使他在商业领域中处于不利地位。

They argued that the new regulations would place their company at a competitive disadvantage in the marketplace.他们认为新规章会使他们公司在市场上处于竞争劣势。

There are advantages and disadvantages to the new system.新制度有有利因素，也有不利因素。

The deal worked to our disadvantage. [=the deal was harmful to us in some way]这笔交易使我们蒙受损失。