The factory closing will deal a serious/severe/devastating/crushing blow to the town's economy.这家工厂的关闭将会给镇上的经济带来严重/沉重/灾难性/毁灭性的打击。

Her career as an ice skater was dealt a fatal blow [=her career was ruined] when she broke her leg.摔断腿对她的溜冰生涯是个致命打击。