The city closed off the beach to tourists.这座城市暂停向游客开放海滩。

closing off a road with barriers用路障封锁道路

Half of the museum was closed off while they made the changes.博物馆整修期间，一半的场馆区域暂停开放。

He closes himself off to new experiences. [=he does not allow himself to have new experiences]他拒绝体验新事物。