It's by no means certain that he'll come. = It's not by any means certain that he'll come.绝不肯定他会来。

This is by no means the first time we have had this problem.这绝不是我们第一次遇到这种问题。

I was not happy about the arrangements by any means, but I agreed to do it.我对这些安排一点也不满意，但我还是同意这么做。

This issue has not been resolved yet by any manner of means.这个问题目前一点也没得到解决。