It receives dopaminergic innervations from ventral tegment area and SNc, and noradrenergic and serotonergic innervations from the locus ceruleus (LC) and dorsal raphe nucleus (DRN), respectively.

腹内侧前额叶皮层主要接受来自腹侧被盖区（ventral tegmental area，VTA）和SNc的DA能神经纤维投射，以及来自蓝斑的去甲肾上腺素（noradrenaline，NA）能和中缝背核的5-HT能神经纤维投射。