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单词 Dendrotoxin
释义

Dendrotoxin

英语百科

Dendrotoxin

3D model of alpha-dendrotoxin. colored in red are positively charged amino acid residues in the N-terminus and the β-turn region that are believed to be important for potassium channel binding.

Dendrotoxins are a class of presynaptic neurotoxins produced by mamba snakes (Dendroaspis) that block particular subtypes of voltage-gated potassium channels in neurons, thereby enhancing the release of acetylcholine at neuromuscular junctions. Because of their high potency and selectivity for potassium channels, dendrotoxins have proven to be extremely useful as pharmacological tools for studying the structure and function of these ion channel proteins.

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