HIV needs to bind to both the CD4 molecule and a coreceptor to get inside the cell.

HIV需要同时结合CD4分子和辅助受体，才能进入细胞。

Well during the chronic phase of HIV infection, it's worth pointing out that some patients develop an X4 strain of HIV which targets the CXCR4 coreceptor, which is essentially only T-cells.

在HIV慢性期，值得指出的是，一些病人体内的HIV病毒出现X4嗜性毒株，结合CXCR4辅助受体，也就是说，只攻击T细胞。

At this early point, during what we call acute infection, the R5 strain of HIV, which bind to the CCR5 coreceptor will get into macrophages, dendritic cells, and T cells.

早期为急性感染期，与CCR5辅助受体相结合的HIV的R5嗜性毒株进入巨噬细胞、树突细胞和T细胞中。

These coreceptors are so important that some people with homogeneous genetic mutations in their CCR5 actually have resistance or immunity to HIV, since HIV can't attach and get into the cell.

对于HIV来讲，辅助受体非常重要，以至于CCR5出现遗传变异的个体会产生HIV抵抗力或免疫力，因为HIV无法通过与其结合进入细胞。