Following impact, immune cells rush in to help clean and repair the damaged site and begin pumping out enzymes, including matrix metalloproteinases and aggrecanases.
关节遭受冲击后，免疫细胞涌入以帮助清理和修复受损部位，并释放包括基质金属蛋白酶和聚集蛋白聚糖酶在内的酶。
| 单词 | Aggrecanase |
| 释义 |
Aggrecanase
原声例句
双语版 TED-Ed 演讲精选 Following impact, immune cells rush in to help clean and repair the damaged site and begin pumping out enzymes, including matrix metalloproteinases and aggrecanases. 关节遭受冲击后，免疫细胞涌入以帮助清理和修复受损部位，并释放包括基质金属蛋白酶和聚集蛋白聚糖酶在内的酶。
英语百科
AggrecanaseAggrecanases are extracellular proteolytic enzymes that are members of the ADAMTS (A Disintegrin And Metalloprotease with Thrombospondin Motifs) family. Aggrecanases act on large proteoglycans known as aggrecans, which are components of connective tissues such as cartilage. The inappropriate activity of aggrecanase is a mechanism by which cartilage degradation occurs in diseases such as arthritis. At least two forms of aggrecanase exist in humans: ADAMTS4 or aggrecanase-1 and ADAMTS5 or aggrecanase-2. Both proteins contain thrombospondin (TS) motifs required for proper recognition of substrates. Although both proteins can cleave the substrate aggrecan at the same position, they differ in kinetics and in secondary cleavage sites. |
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