Contact order

The contact order of a protein is a measure of the locality of the inter-amino acid contacts in the protein's native state tertiary structure. It is calculated as the average sequence distance between residues that form native contacts in the folded protein divided by the total length of the protein. Higher contact orders indicate longer folding times, and low contact order has been suggested as a predictor of potential downhill folding, or protein folding that occurs without a free energy barrier. This effect is thought to be due to the lower loss of conformational entropy associated with the formation of local as opposed to nonlocal contacts.

单词	Contact order
释义	Contact order 原声例句 TED演讲（视频版） 2019年11月合集 In the course of representing that first client at ADX, we learned about another man, Tommy Silverstein, who the Federal Bureau of Prisons put in solitary confinement under a " no human contact" order in 1983, after he killed a corrections officer. 在代表 ADX 的第一个客户的过程中，我们了解到另一个人，汤米西尔弗斯坦，在他杀死一名狱警后，联邦监狱局于 1983 年根据“禁止与人接触” 的命令将他单独监禁。英语百科 Contact order The contact order of a protein is a measure of the locality of the inter-amino acid contacts in the protein's native state tertiary structure. It is calculated as the average sequence distance between residues that form native contacts in the folded protein divided by the total length of the protein. Higher contact orders indicate longer folding times, and low contact order has been suggested as a predictor of potential downhill folding, or protein folding that occurs without a free energy barrier. This effect is thought to be due to the lower loss of conformational entropy associated with the formation of local as opposed to nonlocal contacts.
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