CADASIL syndrome

（重定向自Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy）

A micrograph showing punctate immunostaining (brown) with a Notch 3 antibody, as is characteristic in CADASIL.

CADASIL ("Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy") is the most common form of hereditary stroke disorder, and is thought to be caused by mutations of the Notch 3 gene on chromosome 19. The disease belongs to a family of disorders called the Leukodystrophies. The most common clinical manifestations are migraine headaches and transient ischemic attacks or strokes, which usually occur between 40 and 50 years of age, although MRI is able to detect signs of the disease years prior to clinical manifestation of disease.

单词	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
释义	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy 英语百科 CADASIL syndrome （重定向自Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy） CADASIL ("Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy") is the most common form of hereditary stroke disorder, and is thought to be caused by mutations of the Notch 3 gene on chromosome 19. The disease belongs to a family of disorders called the Leukodystrophies. The most common clinical manifestations are migraine headaches and transient ischemic attacks or strokes, which usually occur between 40 and 50 years of age, although MRI is able to detect signs of the disease years prior to clinical manifestation of disease.
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