Burimamide

Burimamide is an antagonist at the H₂ and H₃ histamine receptors. It is largely inactive as an H₂ antagonist at physiological pH, but its H₃ affinity is 100x higher. It is a thiourea derivative.

Burimamide was first developed by scientists at Smith, Kline & French (SK&F; now GlaxoSmithKline) in their intent to develop a histamine antagonist for the treatment of peptic ulcers. The discovery of burimamide ultimately led to the development of cimetidine (Tagamet).

单词	Burimamide
释义	Burimamide 英语百科 Burimamide Burimamide is an antagonist at the H₂ and H₃ histamine receptors. It is largely inactive as an H₂ antagonist at physiological pH, but its H₃ affinity is 100x higher. It is a thiourea derivative. Burimamide was first developed by scientists at Smith, Kline & French (SK&F; now GlaxoSmithKline) in their intent to develop a histamine antagonist for the treatment of peptic ulcers. The discovery of burimamide ultimately led to the development of cimetidine (Tagamet).
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