穹窿体RNA（英文：Vault RNA，简称vRNA）是一种存在于穹窿体核糖核蛋白复合物中的非编码RNA，该类RNA于1986年被首次发现。作为一种核糖核蛋白复合物，穹窿体除了含有8-16条短链RNA外，还包含96个穹窿体主蛋白（major vault proteins，MVP），两个穹窿体少数蛋白（minor vault proteins，分别为VPARP和TEP1）。 穹窿体被认为与抗药性有关。研究人员已利用冷冻显镜术揭示出vRNA位于穹窿体“帽”底部的内侧。vRNA在穹窿体中的位置可能暗示着穹窿体内外物质都可与其发生相互作用。另有研究发现vRNA需要TEP1以辅助维持自身结构稳定。

Many eukaryotic cells contain large ribonucleoprotein particles in the cytoplasm known as vaults. The vault complex comprises the major vault protein (MVP), two minor vault proteins (VPARP and TEP1), and a variety of small untranslated RNA molecules. Given the association with the nuclear membrane and the location within the cell, vaults are thought to play roles in intracellular and nucleocytoplasmic transport processes. Also, given that the structure and protein composition are highly conserved among species, it is believed that the roles vault plays are integral to eukaryotic function.