In my case, withdrawal has meant a constant, crazed yearning that varies in tolerability throughout the day.

就我而言， 戒断意味着一种持续不断的、疯狂的渴望，这种渴望在一天中的耐受性有所不同。

The study, published in Nature Medicine, describes the first patient treated as part of an international study investigating the safety and tolerability of the treatment.

这项发表在《自然医学》杂志上的研究描述了第一位接受治疗的患者， 该研究是一项调查治疗安全性和耐受性的国际研究的一部分。