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单词 Thymidylate synthase
释义

Thymidylate synthase

英语百科

Thymidylate synthase




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[[<div style=
This shows the overall pathway that thymidylate synthase and it's intermediates take

Thymidylate synthetase (EC2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUTP arise. Both cause DNA damage.

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