SV40 large T antigen

SV40 large T antigen (Simian Vacuolating Virus 40 TAg) is a hexamer protein that is a dominant-acting oncoprotein derived from the polyomavirus SV40. TAg is capable of inducing malignant transformation of a variety of cell types. The transforming activity of TAg is due in large part to its perturbation of the retinoblastoma (pRb) and p53 tumor suppressor proteins. In addition, TAg binds to several other cellular factors, including the transcriptional co-activators p300 and CBP, which may contribute to its transformation function.

单词	T antigen
释义	T antigen 英语百科 SV40 large T antigen SV40 large T antigen (Simian Vacuolating Virus 40 TAg) is a hexamer protein that is a dominant-acting oncoprotein derived from the polyomavirus SV40. TAg is capable of inducing malignant transformation of a variety of cell types. The transforming activity of TAg is due in large part to its perturbation of the retinoblastoma (pRb) and p53 tumor suppressor proteins. In addition, TAg binds to several other cellular factors, including the transcriptional co-activators p300 and CBP, which may contribute to its transformation function.
随便看	disturbed sun disturbed sun noise disturbed test disturbed traverse disturbed upper atmosphere disturbed value disturbed wavefront disturbed weather electricity disturbed zero disturbed zero output disturbed zero output signal disturbed zero output signsl disturber disturbeth Disturbia disturb in disturbing acceleration disturbing admixture disturbing area disturbing body disturbing calculation current of feeding section disturbing cause disturbing channel disturbing current disturbing effect