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单词 Syndecan
释义

Syndecan

英语百科

Syndecan

Ensemble of 16 [syndecan 4] cytoplasmic domain structures displayed over each other. Source PDB 1EJP.

Syndecans are single transmembrane domain proteins that are thought to act as coreceptors, especially for G protein-coupled receptors. These core proteins carry three to five heparan sulfate and chondroitin sulfate chains, which allow for interaction with a large variety of ligands including fibroblast growth factors, vascular endothelial growth factor, transforming growth factor-beta, fibronectin and antithrombin-1. Interactions between fibronectin and some syndecans can be modulated by the extracellular matrix protein tenascin C.

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