Befiradol

Befiradol (F-13,640; NLX-112) is a very potent and highly selective 5-HT_1A receptor full agonist. It has powerful analgesic and antiallodynic effects comparable to those of high doses of opioid painkillers, but with fewer and less prominent side effects, as well as little or no development of tolerance with repeated use. A SAR study revealed that replacement of the dihalophenyl moiety by 3-benzothienyl increases maximal efficacy from 84% to 124% (Ki=2.7 nM).

单词	Befiradol
释义	Befiradol 英语百科 Befiradol Befiradol (F-13,640; NLX-112) is a very potent and highly selective 5-HT_1A receptor full agonist. It has powerful analgesic and antiallodynic effects comparable to those of high doses of opioid painkillers, but with fewer and less prominent side effects, as well as little or no development of tolerance with repeated use. A SAR study revealed that replacement of the dihalophenyl moiety by 3-benzothienyl increases maximal efficacy from 84% to 124% (Ki=2.7 nM).
随便看	cooling cyclone cooling cylinder coolingcylinder cooling debice cooling deformation cooling degree Cooling degree day cooling dehydration cooling device cooling device for the mash cooling device in valves cooling device of machining cooling distribution unit Cooling down cooling down operation cooling down period cooling down rate cooling down test cooling draft cooling drag cooling draught cooling drink cooling drum cooling drum process cooling drums