Pargyline

Pargyline (brand name Eutonyl) is an irreversible selective monoamine oxidase (MAO)-B inhibitor drug (IC₅₀ for MAO-A is 0.01152 µmol/L and for MAO-B is 0.00820 µmol/L) It was brought to market in the US and the UK by Abbott in 1963 as an antihypertensive drug branded "Eutonyl". It was one of several MAO inhibitors introduced in the 1960s including nialamide, isocarboxazid, phenelzine, and tranylcypromine. By 2007 the drug was discontinued and as of 2014 there were no generic versions available in the US. In addition to its actions as an MAOI, pargyline has been found to bind with high affinity to the I₂ imidazoline receptor (an allosteric site on the MAO enzyme).

单词	Supirdyl
释义	Supirdyl 英语百科 Pargyline Pargyline (brand name Eutonyl) is an irreversible selective monoamine oxidase (MAO)-B inhibitor drug (IC₅₀ for MAO-A is 0.01152 µmol/L and for MAO-B is 0.00820 µmol/L) It was brought to market in the US and the UK by Abbott in 1963 as an antihypertensive drug branded "Eutonyl". It was one of several MAO inhibitors introduced in the 1960s including nialamide, isocarboxazid, phenelzine, and tranylcypromine. By 2007 the drug was discontinued and as of 2014 there were no generic versions available in the US. In addition to its actions as an MAOI, pargyline has been found to bind with high affinity to the I₂ imidazoline receptor (an allosteric site on the MAO enzyme).
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Supirdyl

Pargyline