In response to this high-pressure state, the supportive mesangial cells secrete more and more structural matrix expanding the size of the glomerulus.

为了应对这种高压力状态，系膜细胞分泌更多的细胞外基质，增大了肾小球体积。

These growth factors cause the mesangial cells to regress back to their more immature stem cell state known as mesangioblasts and secrete extracellular structural matrix.

这些生长因子使得系膜细胞退化成为未成熟的干细胞状态（成系膜细胞），并分泌细胞外基质框架。